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Mosepele, Mosepele, Ponatshego, Ponego, Molebatsi, Kesaobaka, Williams, Christopher, Mokgatlhe, Lucky, Lockman, Shahin, Youssouf, Nabila, Gross, Robert, Jarvis, Joseph, Wang, Duolao 
ORCID: https://orcid.org/0000-0003-2788-2464 and Jaffar, Shabbar
(2024)
'High prevalence of albuminuria among adult males living with HIV in Botswana'. Scientific Reports, Vol 14, Issue 1, e14432.
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41598_2024_Article_65099.pdf - Published Version Available under License Creative Commons Attribution. Download (936kB) | Preview |
Abstract
Chronic HIV disease is associated with a fivefold increase in albuminuria outside of sub-Saharan Africa. However, very little is known about albuminuria risk among people living with HIV (PLWH) in sub-Saharan Africa. Therefore, we conducted a cross-sectional observational HIV clinic-based study of albuminuria among 1533 adults aged 21 years or older between January 2020 and January 2021 in Gaborone, Botswana. Clinical albuminuria was defined using a sex-based albumin‒creatinine ratio (ACR) of 25–355 mg/g for females and 17–250 mg/g for males. The study population mean age was 48.5 (SD 10.3) years, and 764/1533 (49.7%) were female. The overall prevalence of albuminuria was 20.7% (95% CI 18.7%, 22.8%). A higher proportion of males were more likely to be categorized as having albuminuria than females, 25% (95% CI 22.0, 28.2) versus 16.4% (95% CI 13.8,19.2), P value < 0.001. In the final multivariate models, predictors of albuminuria differed by sex group. Larger longitudinal studies are required to evaluate the impact of albuminuria among PLWH with particular emphasis on the effect of sex on the risk of albuminuria.
| Item Type: | Article |
|---|---|
| Subjects: | WC Communicable Diseases > WC 20 Research (General) WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503 Acquired immunodeficiency syndrome. HIV infections |
| Faculty: Department: | Clinical Sciences & International Health > Clinical Sciences Department |
| Digital Object Identifer (DOI): | https://doi.org/10.1038/s41598-024-65099-w |
| SWORD Depositor: | JISC Pubrouter |
| Depositing User: | JISC Pubrouter |
| Date Deposited: | 02 Jul 2024 13:31 |
| Last Modified: | 02 Jul 2024 13:31 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/24811 |
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