Target product profile choices for intra-domiciliary malaria vector control pesticide products: repel or kill?

Killeen, Gerry ORCID: https://orcid.org/0000-0002-8583-8739, Chitnis, Nakul, Moore, Sarah J and Okumu, Fredros O (2011) 'Target product profile choices for intra-domiciliary malaria vector control pesticide products: repel or kill?'. Malaria Journal, Vol 10, Issue 1, p. 207.

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Abstract

Abstract
Background: The most common pesticide products for controlling malaria-transmitting mosquitoes combine two
distinct modes of action: 1) conventional insecticidal activity which kills mosquitoes exposed to the pesticide and
2) deterrence of mosquitoes away from protected humans. While deterrence enhances personal or household protection of long-lasting insecticidal nets and indoor residual sprays, it may also attenuate or even reverse communal protection if it diverts mosquitoes to non-users rather than killing them outright.

Methods: A process-explicit model of malaria transmission is described which captures the sequential interaction
between deterrent and toxic actions of vector control pesticides and accounts for the distinctive impacts of toxic
activities which kill mosquitoes before or after they have fed upon the occupant of a covered house or sleeping
space.

Results: Increasing deterrency increases personal protection but consistently reduces communal protection
because deterrent sub-lethal exposure inevitably reduces the proportion subsequently exposed to higher lethal doses. If the high coverage targets of the World Health Organization are achieved, purely toxic products with no
deterrence are predicted to generally provide superior protection to non-users and even users, especially where
vectors feed exclusively on humans and a substantial amount of transmission occurs outdoors. Remarkably, this is even the case if that product confers no personal protection and only kills mosquitoes after they have fed.

Conclusions: Products with purely mosquito-toxic profiles may, therefore, be preferable for programmes with universal coverage targets, rather than those with equivalent toxicity but which also have higher deterrence. However, if purely mosquito-toxic products confer little personal protection because they do not deter mosquitoes and only kill them after they have fed, then they will require aggressive “catch up” campaigns, with behaviour change communication strategies that emphasize the communal nature of protection, to achieve high coverage rapidly.

Item Type:	Article
Subjects:	QX Parasitology > Insects. Other Parasites > QX 600 Insect control. Tick control QX Parasitology > Insects. Other Parasites > QX 650 Insect vectors WA Public Health > Preventive Medicine > WA 110 Prevention and control of communicable diseases. Transmission of infectious diseases WA Public Health > Preventive Medicine > WA 240 Disinfection. Disinfestation. Pesticides (including diseases caused by) WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
Faculty: Department:	Groups (2002 - 2012) > Vector Group
Digital Object Identifer (DOI):	https://doi.org/10.1186/1475-2875-10-207
Depositing User:	Users 183 not found.
Date Deposited:	22 Feb 2012 13:58
Last Modified:	16 Sep 2019 10:12
URI:	https://archive.lstmed.ac.uk/id/eprint/2484

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