Does Serum Uric Acid Mediate Relation between Healthy Lifestyle and Components of Metabolic Syndrome?

Huang, Yan, Jing, Hui, Wang, Ziping, Li, Zongkai, Chacha, Samuel, Teng, Yuxin, Mi, Baibing, Zhang, Binyan, Liu, Yezhou, Li, Qiang, Shen, Yuan, Yang, Jiaomei, Qu, Yang, Wang, Duolao ORCID: https://orcid.org/0000-0003-2788-2464, Yan, Hong and Dang, Shaonong (2024) 'Does Serum Uric Acid Mediate Relation between Healthy Lifestyle and Components of Metabolic Syndrome?'. Nutrients, Vol 16, Issue 13, p. 2137.

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Abstract

A healthy lifestyle is related to metabolic syndrome (MetS), but the mechanism is not fully understood. This study aimed to examine the association of components of MetS with lifestyle in a Chinese population and potential mediation role of serum uric acid (SUA) in the association between lifestyle behaviors and risk of components of MetS. Data were derived from a baseline survey of the Shaanxi urban cohort in the Regional Ethnic Cohort Study in northwest China. The relationship between components of MetS, healthy lifestyle score (HLS), and SUA was investigated by logistic or linear regression. A counterfactual-based mediation analysis was performed to ascertain whether and to what extent SUA mediated the total effect of HLS on components of MetS. Compared to those with 1 or less low-risk lifestyle factors, participants with 4–5 factors had 43.6% lower risk of impaired glucose tolerance (OR = 0.564; 95%CI: 0.408~0.778), 60.8% reduction in risk of high blood pressure (OR = 0.392; 95%CI: 0.321~0.478), 69.4% reduction in risk of hypertriglyceridemia (OR = 0.306; 95%CI: 0.252~0.372), and 47.3% lower risk of low levels of HDL cholesterol (OR = 0.527; 95%CI: 0.434~0.641). SUA mediated 2.95% (95%CI: 1.81~6.16%) of the total effect of HLS on impaired glucose tolerance, 14.68% (95%CI: 12.04~18.85%) on high blood pressure, 17.29% (95%CI: 15.01~20.5%) on hypertriglyceridemia, and 12.83% (95%CI: 10.22~17.48%) on low levels of HDL cholesterol. Increased HLS tends to reduce risk of components of MetS partly by decreasing the SUA level, which could be an important mechanism by which lifestyle influences MetS.

Item Type:	Article
Subjects:	QU Biochemistry > Biochemistry of the Human Body > QU 120 Metabolism QU Biochemistry > Vitamins > QU 145 Nutrition. Nutritional requirements
Faculty: Department:	Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):	https://doi.org/10.3390/nu16132137
SWORD Depositor:	JISC Pubrouter
Depositing User:	JISC Pubrouter
Date Deposited:	18 Jul 2024 12:38
Last Modified:	18 Jul 2024 12:38
URI:	https://archive.lstmed.ac.uk/id/eprint/24919

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