Tools
Tools
Debrah, A. Y., Mand, S., Marfo-Debrekyei, Y., Batsa, L., Pfarr, K., Lawson, B., Taylor, Mark 
ORCID: https://orcid.org/0000-0003-3396-9275, Adjei, O. and Hoerauf, A.
(2009)
'Reduction in Levels of Plasma Vascular Endothelial Growth Factor-A and Improvement in Hydrocele Patients by Targeting Endosymbiotic Wolbachia sp in Wuchereria bancrofti with Doxycycline'. American Journal of Tropical Medicine and Hygiene, Vol 80, Issue 6, pp. 956-963.
Abstract
The treatment for hydrocele is expensive, invasive surgery-hydrocelectomy. A drug that could prevent or improve this condition could replace or supplement hydrocelectomy. In Ghana, 42 hydrocele patients participated in a double-blind, placebo-controlled trial of a six-week regimen of doxycycline, 200 mg/day. Four months after doxycycline treatment. patients received 150 mu g/kg of ivermectin and 400 mg of albendazole, which is used for mass chemotherapy in this area. Patients were monitored for levels of Wolbachia sp., microfilaremia, antigenemia, plasma levels of vascular endothelial growth factor-A (VEGF-A) and stage/size of the hydrocele. Wolbachia sp. loads/microfilaria, microfilaremia, and antigenemia were significantly reduced in the doxycycline-treated patients compared with the placebo group. The mean plasma levels of VEGF-A were decreased significantly in the doxycycline-treated patients who had active infection. This finding preceded the reduction of the stage of hydrocele. A six-week regimen of dox
| Item Type: | Article |
|---|---|
| Subjects: | WB Practice of Medicine > Therapeutics > WB 330 Drug therapy WC Communicable Diseases > Tropical and Parasitic Diseases > WC 880 Filariasis and related conditions (General) |
| Digital Object Identifer (DOI): | https://doi.org/10.4269/ajtmh.2009.80.956 |
| Depositing User: | Mary Creegan |
| Date Deposited: | 27 Apr 2010 15:45 |
| Last Modified: | 04 Dec 2024 11:07 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/250 |
Statistics
Actions (login required)
 |
Edit Item |