A case-control study of CYP1A1, GSTT1 and GSTM1 gene polymorphisms, pregnancy smoking and fetal growth restriction

Delpisheh, Ali, Brabin, L., Topping, J., Reyad, M., Tang, A. W. and Brabin, Bernard (2009) 'A case-control study of CYP1A1, GSTT1 and GSTM1 gene polymorphisms, pregnancy smoking and fetal growth restriction'. European Journal of Obstetrics & Gynecology and Reproductive Biology, Vol 143, Issue 1, pp. 38-42.

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Abstract

Objectives: To determine the role of maternal CYP1A1, GSTT1, and GSTM1 metabolic gene polymorphisms in modulating the association between pregnancy smoking exposure and fetal growth restriction.
Study design: A case-control study was conducted to investigate if the association of pregnancy smoking and birth outcome was modulated by maternal gene polymorphisms. A total of 90 mothers with an IUGR baby (cases) and 180 mothers without IUGR (controls) were enrolled.
Results: Almost half of smokers who carried a CYP1A1 variant (51.3%), GSTT1 null (43.6%), or GSTM1 null genotypes (64.1%) delivered a baby with IUGR. Smokers with the variant CYP1A1 "aa" genotype had babies with lower mean birthweight than non-smokers with the same genotype (p = 0.004). An interaction test showed increased prevalence of IUGR in smokers with the CYP1A1 (Aa/aa) variant (adjusted OR, 1.9; 95% CI, 1.4-5.5, p = 0.01), or with the GSTT1 null (AOR, 1.5; 1.1-3.1, p = 0.001), or GSTM1 null genotypes (AOR, 1.5; 1.2-3.7, p = 0.001).
Conclusions: Risk of fetal growth restriction in mothers who smoked during pregnancy was modulated by maternal metabolic gene polymorphisms. The genetic control of the conversion of toxic metabolites of tobacco smoke to less damaging substances is important for maternal and fetal health. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

Item Type:	Article
Uncontrolled Keywords:	iugr genetic pregnancy smoking maternal smoking tobacco-smoke birth-weight genotype association population metabolism exposure placenta nicotine
Subjects:	QT Physiology > Human Physiology > QT 140 Environmental exposure. Physiological adaptation WQ Obstetrics > Pregnancy Complications > WQ 240 Pregnancy complications (General) WQ Obstetrics > Pregnancy > WQ 200 General works QU Biochemistry > Genetics > QU 450 General Works
Faculty: Department:	Groups (2002 - 2012) > Child & Reproductive Health Group
Digital Object Identifer (DOI):	https://doi.org/10.1016/j.ejogrb.2008.11.006
Depositing User:	Pauline Anderson
Date Deposited:	01 Apr 2010 11:40
Last Modified:	06 Feb 2018 12:59
URI:	https://archive.lstmed.ac.uk/id/eprint/251

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