Diverse RNA viruses of parasitic nematodes can elicit antibody responses in vertebrate hosts

Quek, Shannon ORCID: https://orcid.org/0000-0002-1583-9541, Hadermann, Amber, Wu, Yang, De Coninck, Lander, Hegde, Shree ORCID: https://orcid.org/0000-0002-6673-7780, Boucher, Jordan, Cresswell, Jessica, Foreman, Ella, Steven, Andrew, LaCourse, James ORCID: https://orcid.org/0000-0001-9261-7136, Ward, Steve ORCID: https://orcid.org/0000-0003-2331-3192, Wanji, Samuel, Hughes, Grant ORCID: https://orcid.org/0000-0002-7567-7185, Patterson, Edward I., Wagstaff, Simon ORCID: https://orcid.org/0000-0003-0577-5537, Turner, Joseph ORCID: https://orcid.org/0000-0002-2185-5476, Parry, Rhys H., Kohl, Alain, Heinz, Eva ORCID: https://orcid.org/0000-0003-4413-3756, Otabil, Kenneth Bentum, Matthijnssens, Jelle, Colebunders, Robert and Taylor, Mark ORCID: https://orcid.org/0000-0003-3396-9275 (2024) 'Diverse RNA viruses of parasitic nematodes can elicit antibody responses in vertebrate hosts'. Nature Microbiology, Vol 9, Issue 1, pp. 2488-2505.

Preview

Text 2024 Quek RNA Viruses of parasitic nematodes.pdf - Published Version Available under License Creative Commons Attribution. Download (6MB) | Preview

Abstract

Parasitic nematodes have an intimate, chronic and lifelong exposure to vertebrate tissues. Here we mined 41 published parasitic nematode transcriptomes from vertebrate hosts and identified 91 RNA viruses across 13 virus orders from 24 families in ~70% (28 out of 41) of parasitic nematode species, which include only 5 previously reported viruses. We observe widespread distribution of virus–nematode associations across multiple continents, suggesting an ancestral acquisition event and host–virus co-evolution. Characterization of viruses of Brugia malayi (BMRV1) and Onchocerca volvulus (OVRV1) shows that these viruses are abundant in reproductive tissues of adult parasites. Importantly, the presence of BMRV1 RNA in B. malayi parasites mounts an RNA interference response against BMRV1 suggesting active viral replication. Finally, BMRV1 and OVRV1 were found to elicit antibody responses in serum samples from infected jirds and infected or exposed humans, indicating direct exposure to the immune system.

Item Type:	Article
Subjects:	QU Biochemistry > Proteins. Amino Acids. Peptides > QU 58.7 RNA QW Microbiology and Immunology > Antigens and Antibodies. Toxins and Antitoxins > QW 575 Antibodies QX Parasitology > Helminths. Annelida > QX 203 Nematoda QX Parasitology > QX 45 Host-parasite relations
Faculty: Department:	Biological Sciences > Department of Tropical Disease Biology Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):	https://doi.org/10.1038/s41564-024-01796-6
Depositing User:	Clare O'Neill
Date Deposited:	18 Sep 2024 15:32
Last Modified:	10 Oct 2024 11:59
URI:	https://archive.lstmed.ac.uk/id/eprint/25310

Statistics

View details

Actions (login required)

Edit Item