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Elliott, A. M., Kyosiimire, J., Quigley, M. A., Nakiyingi, J., Watera, C., Brown, M., Joseph, S., French, Neil, Gilks, C.F. and Whitworth, J. A. G. (2003) 'Eosinophilia and progression to active tuberculosis in HIV-1-infected Ugandans'. Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol 97, Issue 4, pp. 477-480.
Full text not available from this repository.Abstract
It has been suggested that type 1 immune responses protect against tuberculosis (TB), while type 2 responses, such as those induced by helminths, may suppress protective responses and increase susceptibility to TB. Factors associated with progression to active TB were investigated in a cohort of HIV-1-infected Ugandan adults, a group at high risk of TB. High rates of subsequent progression to active TB were associated with eosinophil counts greater than or equal to 0.4 x 10(9)/L at enrolment. Eosinophilia at enrolment was associated with male gender, low socio-economic status, high CD4+ T cell counts, and schistosomiasis, but adjusting for these factors did not explain the association of eosinophilia with progression to active TB (adjusted rate ratio = 2.76, P = 0.004). Eosinophilia is most likely to be indicative of a type 2 immune response induced by helminth infection in this Ugandan cohort, but the mechanism of the observed association between eosinophilia and risk of TB remains to be determined.
| Item Type: | Article |
|---|---|
| Subjects: | WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503 Acquired immunodeficiency syndrome. HIV infections WF Respiratory System > Tuberculosis > WF 200 Tuberculosis (General) WH Hemic and Lymphatic Systems > Hematologic Diseases. Immunologic Factors. Blood Banks > WH 200 Leukocytes. Leukocyte disorders (General) |
| Digital Object Identifer (DOI): | https://doi.org/10.1016/s0035-9203(03)90096-4 |
| Depositing User: | Users 494 not found. |
| Date Deposited: | 28 Feb 2013 10:21 |
| Last Modified: | 21 Nov 2019 14:45 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/2533 |
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