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Byaruhanga, Timothy, Astbury, Stuart, Hill, Jack D, Tsoleridis, Theocharis, Chappell, Joseph G, Kayiwa, John T, Ataliba, Irene J, Nankya, Annet M, Ball, Jonathan, Lutwama, Julius J and McClure, C Patrick (2024) 'Undiagnosed West Nile virus lineage 2d infection in a febrile patient from South-west Uganda, 2018.'. IJID Regions, Vol 13, e100462.
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Abstract
We report the retrospective identification and subsequent recovery of a near-complete West Nile Virus lineage 2 genomes from a hospitalized patient with acute febrile illness in Uganda, using a combination of degenerate primer polymerase chain reaction screening and a novel 1200bp nanopore-based whole-genome amplicon sequencing scheme. This represents the first West Nile virus genome to be recovered from a human in Uganda since its discovery in 1937. Basic molecular rather than serological surveillance methods could be more widely deployed in the region to better diagnose febrile infections.
| Item Type: | Article |
|---|---|
| Subjects: | QU Biochemistry > Genetics > QU 460 Genomics. Proteomics WB Practice of Medicine > Diagnosis > General Diagnosis > WB 152 Chills. Fever |
| Faculty: Department: | Biological Sciences > Department of Tropical Disease Biology |
| Digital Object Identifer (DOI): | https://doi.org/10.1016/j.ijregi.2024.100462 |
| Related URLs: | |
| SWORD Depositor: | JISC Pubrouter |
| Depositing User: | JISC Pubrouter |
| Date Deposited: | 18 Nov 2024 13:52 |
| Last Modified: | 18 Nov 2024 13:52 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/25580 |
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