The burden of bacterial antimicrobial resistance in the WHO African region in 2019: a cross-country systematic analysis

Sartorius, Benn, Gray, Authia P, Davis Weaver, Nicole, Robles Aguilar, Gisela, Swetschinski, Lucien R, Ikuta, Kevin S, Mestrovic, Tomislav, Chung, Erin, Wool, Eve E, Han, Chieh, Gershberg Hayoon, Anna, Araki, Daniel T, Abd-Elsalam, Sherief, Aboagye, Richard Gyan, Adamu, Lawan Hassan, Adepoju, Abiola Victor, Ahmed, Ayman, Akalu, Gizachew Taddesse, Akande-Sholabi, Wuraola, Amuasi, John H, Amusa, Ganiyu Adeniyi, Argaw, Ayele Mamo, Aruleba, Raphael Taiwo, Awoke, Tewachew, Ayalew, Melese Kitu, Azzam, Ahmed Y, Babin, Francois-Xavier, Banerjee, Indrajit, Basiru, Afisu, Bayileyegn, Nebiyou Simegnew, Belete, Melaku Ashagrie, Berkley, James A, Bielicki, Julia A, Dekker, Denise, Demeke, Dessalegn, Demsie, Desalegn Getnet, Dessie, Anteneh Mengist, Dunachie, Susanna J, Ed-Dra, Abdelaziz, Ekholuenetale, Michael, Ekundayo, Temitope Cyrus, El Sayed, Iman, Elhadi, Muhammed, Elsohaby, Ibrahim, Eyre, David, Fagbamigbe, Adeniyi Francis, Feasey, Nicholas ORCID: https://orcid.org/0000-0003-4041-1405, Fekadu, Ginenus, Fell, Frederick, Forrest, Karen M, Gebrehiwot, Mesfin, Gezae, Kebede Embaye, Ghazy, Ramy Mohamed, Hailegiyorgis, Tewodros Tesfa, Haines-Woodhouse, Georgina, Hasaballah, Ahmed I, Haselbeck, Andrea Haekyung, Hsia, Yingfen, Iradukunda, Arnaud, Iregbu, Kenneth Chukwuemeka, Iwu, Chidozie C D, Iwu-Jaja, Chinwe Juliana, Iyasu, Assefa N, Jaiteh, Fatoumatta, Jeon, Hyonjin, Joshua, Charity Ehimwenma, Kassa, Gebrehiwot G, Katoto, Patrick DMC, Krumkamp, Ralf, Kumaran, Emmanuelle A P, Kyu, Hmwe Hmwe, Manilal, Aseer, Marks, Florian, May, Jürgen, McLaughlin, Susan A, McManigal, Barney, Melese, Addisu, Misgina, Kebede Haile, Mohamed, Nouh Saad, Mohammed, Mustapha, Mohammed, Shafiu, Mohammed, Shikur, Mokdad, Ali H, Moore, Catrin E, Mougin, Vincent, Mturi, Neema, Mulugeta, Temesgen, Musaigwa, Fungai, Musicha, Patrick, Musila, Lillian A, Muthupandian, Saravanan, Naghavi, Pirouz, Negash, Hadush, Nuckchady, Dooshanveer C, Obiero, Christina W, Odetokun, Ismail A, Ogundijo, Oluwaseun Adeolu, Okidi, Lawrence, Okonji, Osaretin Christabel, Olagunju, Andrew T, Olufadewa, Isaac Iyinoluwa, Pak, Gi Deok, Perovic, Olga, Pollard, Andrew, Raad, Mathieu, Rafaï, Clotaire, Ramadan, Hazem, Redwan, Elrashdy Moustafa Mohamed, Roca, Anna, Rosenthal, Victor Daniel, Saleh, Mohamed A, Samy, Abdallah M, Sharland, M, Shittu, Aminu, Siddig, Emmanuel Edwar, Sisay, Eskinder Ayalew, Stergachis, Andy, Tesfamariam, Wegen Beyene, Tigoi, Caroline, Tincho, Marius Belmondo, Tiruye, Tenaw Yimer, Umeokonkwo, Chukwuma David, Walsh, Timothy, Walson, Judd L, Yusuf, Hadiza, Zeru, Naod Gebrekrstos, Hay, Simon I, Dolecek, Christiane, Murray, Christopher J L and Naghavi, Mohsen (2023) 'The burden of bacterial antimicrobial resistance in the WHO African region in 2019: a cross-country systematic analysis'. Lancet Global Health, Vol 12, Issue 2, e201-e216.

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Abstract

Background A critical and persistent challenge to global health and modern health care is the threat of antimicrobial resistance (AMR). Previous studies have reported a disproportionate burden of AMR in low-income and middle-income countries, but there remains an urgent need for more in-depth analyses across Africa. This study presents one of the most comprehensive sets of regional and country-level estimates of bacterial AMR burden in the WHO
African region to date.
Methods We estimated deaths and disability-adjusted life-years (DALYs) attributable to and associated with AMR for 23 bacterial pathogens and 88 pathogen–drug combinations for countries in the WHO African region in 2019. Our methodological approach consisted of five broad components: the number of deaths in which infection had a role, the proportion of infectious deaths attributable to a given infectious syndrome, the proportion of infectious syndrome deaths attributable to a given pathogen, the percentage of a given pathogen resistant to an antimicrobial drug of interest, and the excess risk of mortality (or duration of an infection) associated with this resistance. These components were then used to estimate the disease burden by using two counterfactual scenarios: deaths attributable to AMR (considering an alternative scenario where infections with resistant pathogens are replaced with susceptible ones) and deaths
associated with AMR (considering an alternative scenario where drug-resistant infections would not occur at all). We obtained data from research hospitals, surveillance networks, and infection databases maintained by private laboratories and medical technology companies. We generated 95% uncertainty intervals (UIs) for final estimates as the 25th and 975th ordered values across 1000 posterior draws, and models were cross-validated for out-of-sample predictive validity.
Findings In the WHO African region in 2019, there were an estimated 1·05 million deaths (95% UI 829 000–1 316000) associated with bacterial AMR and 250000 deaths (192000–325000) attributable to bacterial AMR. The largest fatal AMR burden was attributed to lower respiratory and thorax infections (119 000 deaths [92 000–151 000], or 48% of all estimated bacterial pathogen AMR deaths), bloodstream infections (56000 deaths [37000–82000], or 22%), intra-abdominal infections (26 000 deaths [17 000–39000], or 10%), and tuberculosis (18 000 deaths [3850–39 000], or 7%). Seven leading pathogens were collectively responsible for 821 000 deaths (636 000–1 051 000) associated with resistance in this region, with four pathogens exceeding 100 000 deaths each: Streptococcus pneumoniae, Klebsiella pneumoniae, Escherichia coli, and Staphylococcus aureus. Third-generation cephalosporin-resistant K pneumoniae and meticillin-resistant S aureus were shown to be the leading pathogen–drug combinations in 25 and 16 countries, respectively (53% and 34% of the whole region, comprising 47 countries) for deaths attributable to AMR.
Interpretation This study reveals a high level of AMR burden for several bacterial pathogens and pathogen–drug combinations in the WHO African region. The high mortality rates associated with these pathogens demonstrate an urgent need to address the burden of AMR in Africa. These estimates also show that quality and access to health care and safe water and sanitation are correlated with AMR mortality, with a higher fatal burden found in lower resource
settings. Our cross-country analyses within this region can help local governments to leverage domestic and global funding to create stewardship policies that target the leading pathogen–drug combinations.

Item Type:	Article
Subjects:	QW Microbiology and Immunology > QW 45 Microbial drug resistance. General or not elsewhere classified. QW Microbiology and Immunology > QW 50 Bacteria (General). Bacteriology. Archaea
Faculty: Department:	Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):	https://doi.org/10.1016/s2214-109x(23)00539-9
Depositing User:	Mary Creegan
Date Deposited:	17 Dec 2024 14:54
Last Modified:	17 Dec 2024 14:54
URI:	https://archive.lstmed.ac.uk/id/eprint/25769

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