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Jones, M., Mercer, A. E., Stocks, Paul A., La Pensee, L. J. I., Cosstick, R., Park, B. K., Kennedy, M. E., Piantanida, I., Ward, Stephen 
ORCID: https://orcid.org/0000-0003-2331-3192, Davies, Jill, Bray, Patrick, Rawe, S. L., Baird, J., Charidza, T., Janneh, O. and O'Neill, P. M.
(2009)
'Antitumour and antimalarial activity of artemisinin-acridine hybrids'. Bioorganic & Medicinal Chemistry Letters, Vol 19, Issue 7, pp. 2033-2037.
Abstract
Artemisinin-acridine hybrids were prepared and evaluated for their in vitro activity against tumour cell lines and a chloroquine sensitive strain of Plasmodium falciparum. They showed a 2-4-fold increase in activity against HL60, MDA-MB-231 and MCF-7 cells in comparison with dihydroartemisinin (DHA) and moderate antimalarial activity. Strong evidence that the compounds induce apoptosis in HL60 cells was obtained by flow cytometry, which indicated accumulation of cells in the G1 phase of the cell cycle. (C) 2009 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | artemisinin acridine antimalarial anticancer apoptosis DNA confocal microscopy tumor-cells DNA cytotoxicity dihydroartemisinin intercalation endoperoxides derivatives artesunate complexes chemistry |
| Subjects: | QZ Pathology > Neoplasms. Cysts > QZ 200 Neoplasms. Cysts (General) QV Pharmacology > Anti-Inflammatory Agents. Anti-Infective Agents. Antineoplastic Agents > QV 256 Antimalarials QV Pharmacology > Anti-Inflammatory Agents. Anti-Infective Agents. Antineoplastic Agents > QV 254 Antiprotozoal agents (General) |
| Faculty: Department: | Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group |
| Digital Object Identifer (DOI): | https://doi.org/10.1016/j.bmcl.2009.02.028 |
| Depositing User: | Mary Creegan |
| Date Deposited: | 24 Jun 2010 14:34 |
| Last Modified: | 17 Jul 2020 10:56 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/293 |
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