Expression of tissue factor, the clotting initiator, on macrophages in Plasmodium falciparum-infected placentas

Imamura, T., Sugiyama, T., Cuevas, Luis ORCID: https://orcid.org/0000-0002-6581-0587, Makunde, R. and Nakamura, S. (2002) 'Expression of tissue factor, the clotting initiator, on macrophages in Plasmodium falciparum-infected placentas'. Journal of Infectious Disease, Vol 186, Issue 3, pp. 436-440.

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Abstract

The expression of tissue factor (TF), the initiator of the clotting system, was investigated by immunohistochemical staining for its role in clotting mechanisms of Plasmodium falciparum-infected placenta. Most mononuclear cells in the intervillous space of infected placentas stained with an anti-TF monoclonal antibody (MAb) and were positive for antimacrophage MAb. The intervillous space of infected placentas had significant fibrin deposition. In contrast, only small amounts of leukocytes, TF-positive cells, and fibrin were seen in the intervillous space in noninfected placentas. These results indicate that macrophages accumulated in infected placentas express TF and that subsequent perivillous fibrin clot formation leads to a narrowing and plugging of the intervillous space and disturbance of the blood supply. Macrophage TF expression in placentas could be associated with retarded placental growth and low birth weight in malaria infection and should be further investigated.

Item Type:	Article
Subjects:	WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria WH Hemic and Lymphatic Systems > Hematologic Diseases. Immunologic Factors. Blood Banks > WH 150 Erythrocytes WH Hemic and Lymphatic Systems > Hematologic Diseases. Immunologic Factors. Blood Banks > WH 310 Mechanism of blood coagulation. Hemostatis WH Hemic and Lymphatic Systems > Lymphatic System > WH 650 Reticuloendothelial system WQ Obstetrics > Pregnancy Complications > WQ 256 Infectious diseases
Digital Object Identifer (DOI):	https://doi.org/10.1086/341507
Depositing User:	Lynn Roberts-Maloney
Date Deposited:	31 Jul 2013 13:38
Last Modified:	07 Dec 2018 09:39
URI:	https://archive.lstmed.ac.uk/id/eprint/2941

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