Prevalence, incidence, and mother-to-child transmission of HIV-1 in rural South Africa

Rollins, N. C., Dedicoat, Martin, Danaviah, S., Page, T., Bishop, K., Kleinschmidt, I., Coovadia, H. M. and Cassol, S. A. (2002) 'Prevalence, incidence, and mother-to-child transmission of HIV-1 in rural South Africa'. Lancet, Vol 360, Issue 9330, pp. 389-390.

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Abstract

Simple, robust approaches are needed to monitor prevalence, incidence, and mother-to-child transmission of HIV-1 in rural Africa. We have designed a method that uses antibody and viral RNA testing of dried blood spots obtained from mother-infant pairs attending routine immunisation clinics. In our study, prevalence and incidence of HIV-1 was highest in young women in their late teens and early twenties. In children born to infected mothers, prevalence increased from 14% in infants younger than 6 weeks of age to 24% at 3-6 months. The blood-spot approach is an effective method for surveillance of HIV-1 in women and children, and for early identification of incidence of this infection in women of child-bearing age.

Item Type:	Article
Subjects:	WA Public Health > Health Problems of Special Population Groups > WA 310 Maternal welfare WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503 Acquired immunodeficiency syndrome. HIV infections WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503.3 Etiology. Transmission WS Pediatrics > By Age Groups > WS 430 Infancy
Digital Object Identifer (DOI):	https://doi.org/10.1016/s0140-6736(02)09599-5
Depositing User:	Lynn Roberts-Maloney
Date Deposited:	11 Jul 2013 13:39
Last Modified:	18 May 2018 14:25
URI:	https://archive.lstmed.ac.uk/id/eprint/2981

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