The role of endosymbiotic Wolbachia bacteria in the pathogenesis of river blindness

Saint Andre, A. V., Blackwell, N. M., Hall, L. R., Hoerauf, A., Brattig, N. W., Volkmann, L., Taylor, Mark ORCID: https://orcid.org/0000-0003-3396-9275, Ford, Louise, Hise, A. G., Lass, J. H., Diaconu, E. and Pearlman, E. (2002) 'The role of endosymbiotic Wolbachia bacteria in the pathogenesis of river blindness'. Science, Vol 295, Issue 5561, pp. 1892-1895.

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Abstract

Parasitic filarial nematodes infect more than 200 million individuals worldwide, causing debilitating inflammatory diseases such as river blindness and lymphatic filariasis. Using a murine model for river blindness in which soluble extracts of filarial nematodes were injected into the corneal stroma, we demonstrated that the predominant inflammatory response in the cornea was due to species of endosymbiotic Wolbachia bacteria. In addition, the inflammatory response induced by these bacteria was dependent on expression of functional Toll-like receptor 4 (TLR4) on host cells.

Item Type:	Article
Subjects:	QX Parasitology > Helminths. Annelida > QX 301 Filarioidea WC Communicable Diseases > Rickettsiaceae Infections. Chlamydiaceae Infections > WC 600 Rickettsiaceae infections. Chlamydiaceae infections. Tick-borne diseases WC Communicable Diseases > Tropical and Parasitic Diseases > WC 880 Filariasis and related conditions (General)
Faculty: Department:	Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI):	https://doi.org/10.1126/science.1068732
Depositing User:	Martin Chapman
Date Deposited:	13 Aug 2013 15:43
Last Modified:	16 Sep 2019 09:01
URI:	https://archive.lstmed.ac.uk/id/eprint/2983

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