Flying tryps: survival and maturation of trypanosomes in tsetse flies

Dyer, Naomi, Rose, Clair ORCID: https://orcid.org/0000-0001-7782-5359, Ejeh, Nicholas and Acosta Serrano, Alvaro ORCID: https://orcid.org/0000-0002-2576-7959 (2013) 'Flying tryps: survival and maturation of trypanosomes in tsetse flies'. Trends in Parasitology, Vol 29, Issue 4, pp. 188-196.

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Abstract

Survival in and colonization of the tsetse fly midgut are essential steps in the transmission of many species of African trypanosomes. In the fly, bloodstream trypanosomes transform into the procyclic stage within the gut lumen and later migrate to the ectoperitrophic space, where they multiply, establishing an infection. Progression of the parasite infection in the fly depends on factors inherent to the biology of trypanosomes, tsetse, and the bloodmeal. Flies usually eradicate infection early on with both pre-existing and inducible factors. Parasites, in contrast, respond to these stimuli by undergoing developmental changes, allowing a few to both survive and migrate within the tsetse. Here we discuss parasite and fly factors determining trypanosome colonization of the tsetse, focusing mainly on the midgut.

Item Type:	Article
Subjects:	QX Parasitology > QX 45 Host-parasite relations QX Parasitology > Insects. Other Parasites > QX 505 Diptera QX Parasitology > Protozoa > QX 70 Mastigophora. (e.g., Giardia. Trichomonas. Trypanosoma. Leishmania) WC Communicable Diseases > Tropical and Parasitic Diseases > WC 705 Trypanosomiasis
Faculty: Department:	Biological Sciences > Department of Tropical Disease Biology Biological Sciences > Vector Biology Department
Digital Object Identifer (DOI):	https://doi.org/10.1016/j.pt.2013.02.003
Depositing User:	Samantha Sheldrake
Date Deposited:	10 Jul 2013 09:42
Last Modified:	07 Jun 2022 11:09
URI:	https://archive.lstmed.ac.uk/id/eprint/3421

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