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Naghipour, M., Hart, C. Anthony, Dove, W., Leatherbarrow, A. J. H. and Cuevas, Luis 
ORCID: https://orcid.org/0000-0002-6581-0587
(2009)
'Adenovirus Infections Within a Family Cohort in Iran'. Pediatric Pulmonology, Vol 44, Issue 8, pp. 749-753.
Abstract
Background: Adenovirus is one of the most frequent viruses associated with acute respiratory infections (ARI). There is limited information of its transmission within the community. Methods: Cohorts of 50 families with >= two children were visited weekly for 2 months to ascertain the presence ARI in Rasht, Iran. Nasopharyngeal swabs were obtained from symptomatic participants and at 3-4-day intervals to assess the duration of adenovirus shedding. Adenoviruses were identified by PCR and adenovirus positive amplicons were subjected to DNA sequencing. Results: Thirty-three (35%) of 94 ARI episodes in children and 8 (27%) of 30 episodes in adults were due to adenovirus (not significant, NS). 25/50 (50%) families had adenovirus infections. Children had more infections than adults, were more likely to develop symptoms if there was a symptomatic case within the household and episodes had a longer duration (P < 0.05). Adenoviruses were recovered for a median of 11 (interquartile range 5-26) days of follow up in children and 7 (2-20) days in adults (NS). Adenovirus-7 was the most frequent serotype (12 families), followed by adenovirus-6 (5 families), adenovirus-1 and 2 (4 families each), and adenovirus-5 (3 families). Both adenovirus-5 and 7 amplicons fell into two clusters. No mutations were observed during transmission within a family. Conclusion A substantial proportion of ARI in the community are due to adenovirus with further transmission within the family Children >= 2 years experienced a higher proportion of infections than younger children and adults. Viral shedding was more prolonged in children and adenovirus-7 and 5 predominated with several clusters co-circulating in the same season. Pediatr Pulmonol. 2009; 44:749-753. (C) 2009 Wiley-Liss, Inc.
| Item Type: | Article |
|---|---|
| Additional Information: | Naghipour, Mohammadreza Hart, C. Anthony Dove, Winifred Leatherbarrow, A. J. Howard Cuevas, Luis E. |
| Subjects: | WB Practice of Medicine > Medical Climatology > WB 710 Diseases of geographic areas WF Respiratory System > WF 20 Research (General) QW Microbiology and Immunology > Viruses > QW 160 Viruses (General). Virology WC Communicable Diseases > Virus Diseases > General Virus Diseases > WC 500 Virus diseases (General or not elsewhere classified) WF Respiratory System > WF 100 General works WF Respiratory System > WF 140 Diseases of the respiratory system (General) QY Clinical Pathology > QY 4 General works |
| Faculty: Department: | Groups (2002 - 2012) > Child & Reproductive Health Group |
| Digital Object Identifer (DOI): | https://doi.org/10.1002/ppul.20785 |
| Depositing User: | Pauline Anderson |
| Date Deposited: | 26 Mar 2010 14:41 |
| Last Modified: | 06 Feb 2018 12:59 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/343 |
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