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Attardo, G. M., Abila, P. P., Auma, J. E., Baumann, A. A., Benoit, J. B., Brelsfoard, C. L., Ribeiro, J. M. C., Cotton, J. A., Pham, D. Q. D., Darby, Alistair C., Van Den Abbeele, J., Denlinger, D. L., Field, L. M., Nyanjom, S. R. G., Gaunt, M. W., Geiser, D. L., Gomulski, L. M., Haines, Lee 
ORCID: https://orcid.org/0000-0001-8821-6479, Hansen, I. A., Jones, J. W., Kibet, C. K., Kinyua, J. K., Larkin, D. M., Lehane, Mike, Rio, R. V. M., Macdonald, S. J., Macharia, R. W., Malacrida, A. R., Marco, H. G., Marucha, K. K., Masiga, D. K., Meuti, M. E., Mireji, P. O., Obiero, G. F. O., Koekemoer, J. J. O., Okoro, C. K., Omedo, I. A., Osamor, V. C., Balyeidhusa, A. S. P., Peyton, J. T., Price, D. P., Quail, M. A., Ramphul, U., Rawlings, N. D., Riehle, M. A., Robertson, H. M., Sanders, M. J., Scott, M. J., Dashti, Z. J. S., Snyder, A. K., Srivastava, T. P., Stanley, E. J., Swain, M. T., Hughes, D. S. T., Tarone, A. M., Taylor, T. D., Telleria, E. L., Thomas, G. H., Walshe, Deirdre ORCID: https://orcid.org/0000-0001-5531-2368, Wilson, R. K., Winzerling, J. J., Acosta Serrano, Alvaro ORCID: https://orcid.org/0000-0002-2576-7959, Aksoy, S., Arensburger, P., Aslett, M., Bateta, R., Benkahla, A., Berriman, M., Bourtzis, K., Caers, J., Caljon, G., Christoffels, A., Falchetto, M., Friedrich, M., Fu, S., Gade, G., Githinji, G., Gregory, R., Hall, N., Harkins, G., Hattori, M., Hertz-Fowler, C., Hide, W., Hu, W., Imanishi, T., Inoue, N., Jonas, M., Kawahara, Y., Koffi, M., Kruger, A., Lawson, D., Lehane, Stella, Lehvaslaiho, H., Luiz, T., Makgamathe, M., Malele, I., Manangwa, O., Manga, L., Megy, K., Michalkova, V., Mpondo, F., Mramba, F., Msangi, A., Mulder, N., Murilla, G., Mwangi, S., Okedi, L., Ommeh, S., Ooi, Cher-Pheng, Ouma, J., Panji, S., Ravel, S., Rose, Clair ORCID: https://orcid.org/0000-0001-7782-5359, Sakate, R., Schoofs, L., Scolari, F., Sharma, V., Sim, C., Siwo, G., Solano, P., Stephens, D., Suzuki, Y., Sze, S.-H., Toure, Y., Toyoda, A., Tsiamis, G., Tu, Z., Wamalwa, M., Wamwiri, F., Wang, J., Warren, W., Watanabe, J., Weiss, B., Willis, J., Wincker, P., Zhang, Q. and Zhou, J.-J.
(2014)
'Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African Trypanosomiasis'. Science, Vol 344, Issue 6182, pp. 380-386.
Abstract
Tsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes of adult tsetse feed exclusively on blood and contribute to disease transmission. Notable differences between tsetse and other disease vectors include obligate microbial symbioses, viviparous reproduction, and lactation. Here, we describe the sequence and annotation of the 366-megabase Glossina morsitans morsitans genome. Analysis of the genome and the 12,308 predicted protein-encoding genes led to multiple discoveries, including chromosomal integrations of bacterial (Wolbachia) genome sequences, a family of lactation-specific proteins, reduced complement of host pathogen recognition proteins, and reduced olfaction/chemosensory associated genes. These genome data provide a foundation for research into trypanosomiasis prevention and yield important insights with broad implications for multiple aspects of tsetse biology.
| Item Type: | Article |
|---|---|
| Additional Information: | Published by the members of the International Glossina Genome Initiative (IGGI). |
| Subjects: | QU Biochemistry > Genetics > QU 470 Genetic structures QX Parasitology > Insects. Other Parasites > QX 505 Diptera WC Communicable Diseases > Tropical and Parasitic Diseases > WC 705 Trypanosomiasis |
| Faculty: Department: | Biological Sciences > Department of Tropical Disease Biology Biological Sciences > Vector Biology Department |
| Digital Object Identifer (DOI): | https://doi.org/10.1126/science.1249656 |
| Depositing User: | Martin Chapman |
| Date Deposited: | 08 May 2014 10:40 |
| Last Modified: | 17 Jul 2020 10:57 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/3682 |
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