Schistosoma mansoni infection in preschool-aged children: development of immunoglobulin E and immunoglobulin G4 responses to parasite allergen-like proteins.

Pinot de Moira, Angela, Sousa-Figueiredo, J.C., Jones, Frances M, Fitzsimmons, Colin M, Betson, Martha, Kabatereine, Narcis B, Stothard, J Russell ORCID: https://orcid.org/0000-0002-9370-3420 and Dunne, David W (2013) 'Schistosoma mansoni infection in preschool-aged children: development of immunoglobulin E and immunoglobulin G4 responses to parasite allergen-like proteins.'. Journal of Infectious Disease, Vol 207, Issue 2, pp. 362-366.

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Abstract

Specific immunoglobulin E (IgE) responses are upregulated during chronic schistosome infection and during allergy. These responses are tightly regulated during schistosomiasis. We have previously shown that IgE regulation depends on the extent and length of exposure to individual parasite allergen-like proteins. Here we compare the development of IgE and immunoglobulin G4 (IgG(4)) responses to the differentially expressed allergen-like proteins SmTAL1 and SmTAL2 among preschool-aged children from 2 villages with different levels of Schistosoma mansoni transmission. We found a lack of SmTAL1 responsiveness among all children, but evidence for IgG(4)-dependent IgE-SmTAL2 desensitization in both villages, occurring earlier among children from the village where the level of transmission was greater. Findings provide insights into the development and regulation of allergic-type immune responses.

Item Type:	Article
Subjects:	QW Microbiology and Immunology > Reference Works. General Immunology > QW 520 Research (General) QW Microbiology and Immunology > Antigens and Antibodies. Toxins and Antitoxins > QW 575 Antibodies QX Parasitology > Helminths. Annelida > QX 355 Schistosoma WC Communicable Diseases > Tropical and Parasitic Diseases > WC 810 Schistosomiasis WS Pediatrics > By Age Groups > WS 440 Preschool child
Digital Object Identifer (DOI):	https://doi.org/10.1093/infdis/jis676
Depositing User:	Mary Creegan
Date Deposited:	30 Jul 2014 09:02
Last Modified:	02 Dec 2019 12:52
URI:	https://archive.lstmed.ac.uk/id/eprint/3812

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