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Wu, Bo, Novelli, Jacopo, Jiang, Daojun, Dailey, Harry A, Landmann, Frédéric, Ford, Louise, Taylor, Mark 
ORCID: https://orcid.org/0000-0003-3396-9275, Carlow, Clotilde K S, Kumar, Sanjay, Foster, Jeremy M and Slatko, Barton E
(2013)
'Interdomain lateral gene transfer of an essential ferrochelatase gene in human parasitic nematodes.'. Proceedings of the National Academy of Sciences, Vol 110, Issue 19, pp. 7748-7753.
Abstract
Lateral gene transfer events between bacteria and animals highlight an avenue for evolutionary genomic loss/gain of function. Herein, we report functional lateral gene transfer in animal parasitic nematodes. Members of the Nematoda are heme auxotrophs, lacking the ability to synthesize heme; however, the human filarial parasite Brugia malayi has acquired a bacterial gene encoding ferrochelatase (BmFeCH), the terminal step in heme biosynthesis. BmFeCH, encoded by a 9-exon gene, is a mitochondrial-targeted, functional ferrochelatase based on enzyme assays, complementation, and inhibitor studies. Homologs have been identified in several filariae and a nonfilarial nematode. RNAi and ex vivo inhibitor experiments indicate that BmFeCH is essential for viability, validating it as a potential target for filariasis control.
| Item Type: | Article |
|---|---|
| Subjects: | QU Biochemistry > Genetics > QU 475 Genetic processes QX Parasitology > Helminths. Annelida > QX 203 Nematoda WC Communicable Diseases > Tropical and Parasitic Diseases > WC 880 Filariasis and related conditions (General) |
| Faculty: Department: | Biological Sciences > Department of Tropical Disease Biology |
| Digital Object Identifer (DOI): | https://doi.org/10.1073/pnas.1304049110 |
| Depositing User: | Mary Creegan |
| Date Deposited: | 13 Aug 2014 09:04 |
| Last Modified: | 16 Sep 2019 09:01 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/3840 |
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