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Fraser, C., Lythgoe, K., Leventhal, G. E., Shirreff, G., Hollingsworth, Deirdre, Alizon, S. and Bonhoeffer, S. (2014) 'Virulence and Pathogenesis of HIV-1 Infection: An Evolutionary Perspective'. Science, Vol 343, Issue 6177, p. 1328.
Full text not available from this repository.Abstract
Why some individuals develop AIDS rapidly whereas others remain healthy without treatment for many years remains a central question of HIV research. An evolutionary perspective reveals an apparent conflict between two levels of selection on the virus. On the one hand, there is rapid evolution of the virus in the host, and on the other, new observations indicate the existence of virus factors that affect the virulence of infection whose influence persists over years in infected individuals and across transmission events. Here, we review recent evidence that shows that viral genetic factors play a larger role in modulating disease severity than anticipated. We propose conceptual models that reconcile adaptive evolution at both levels of selection. Evolutionary analysis provides new insight into HIV pathogenesis.
| Item Type: | Article |
|---|---|
| Subjects: | QZ Pathology > Pathogenesis. Etiology > QZ 40 Pathogenesis. Etiology WC Communicable Diseases > WC 20 Research (General) WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503 Acquired immunodeficiency syndrome. HIV infections |
| Faculty: Department: | Clinical Sciences & International Health > Clinical Sciences Department |
| Digital Object Identifer (DOI): | https://doi.org/10.1126/science.1243727 |
| Depositing User: | Lynn Roberts-Maloney |
| Date Deposited: | 05 Sep 2014 14:16 |
| Last Modified: | 06 Feb 2018 13:07 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/4443 |
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