Micronutrients and sickle cell disease, effects on growth, infection and vaso-occlusive crisis: A systematic review

Dekker, Louise H., Fijnvandraat, Karin, Brabin, Bernard and van Hensbroek, Michael Boele (2012) 'Micronutrients and sickle cell disease, effects on growth, infection and vaso-occlusive crisis: A systematic review'. Pediatric Blood and Cancer, Vol 59, Issue 2, pp. 211-215.

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Abstract

Patients with Sickle cell disease (SCD) exhibit signs of poor growth, increased susceptibility to infection and recurrent episodes of painful vaso-occlusive crises. Micronutrient deficiencies may increase susceptibility to these outcomes. We conducted a systematic review to assess the strength of evidence for improved outcomes related to micronutrient interventions. Six randomized-controlled trials of moderate quality met the inclusion criteria. Zinc supplementation was associated with improved growth and decreased incidence of infection and is a promising intervention in the management of SCD patients. Omega-3 fatty acid supplementation was associated with limited reduction in vaso occlusive crises. This review identifies key knowledge gaps, which are important research priorities for nutritional interventions.

Item Type:	Article
Subjects:	QU Biochemistry > Vitamins > QU 145 Nutrition. Nutritional requirements WD Disorders of Systemic, Metabolic or Environmental Origin, etc > Nutrition Disorders > WD 105 Deficiency diseases WH Hemic and Lymphatic Systems > Hematologic Diseases. Immunologic Factors. Blood Banks > WH 170 Hemolytic anemia (e.g., Sickle cell anemia)
Faculty: Department:	Groups (2002 - 2012) > Child & Reproductive Health Group
Digital Object Identifer (DOI):	https://doi.org/10.1002/pbc.24163
Depositing User:	Lynn Roberts-Maloney
Date Deposited:	05 Jan 2015 11:05
Last Modified:	06 Feb 2018 13:08
URI:	https://archive.lstmed.ac.uk/id/eprint/4700

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