Pattern recognition receptor-mediated cytokine response in infants across 4 continents⋆

Smolen, Kinga K., Ruck, Candice E., Fortuno, Edgardo S., Ho, Kevin, Dimitriu, Pedro, Mohn, William W., Speert, David P., Cooper, Philip, Esser, Monika, Goetghebuer, Tessa, Marchant, Arnaud and Kollmann, Tobias R. (2014) 'Pattern recognition receptor-mediated cytokine response in infants across 4 continents⋆'. Journal of Allergy and Clinical Immunology, Vol 133, Issue 3, pp. 818-826.

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Abstract

Background

Susceptibility to infection as well as response to vaccination varies among populations. To date, the underlying mechanisms responsible for these clinical observations have not been fully delineated. Because innate immunity instructs adaptive immunity, we hypothesized that differences between populations in innate immune responses may represent a mechanistic link to variation in susceptibility to infection or response to vaccination.

Objective

Determine whether differences in innate immune responses exist among infants from different continents of the world.

Methods

We determined the innate cytokine response following pattern recognition receptor (PRR) stimulation of whole blood from 2-year-old infants across 4 continents (Africa, North America, South America, and Europe).

Results

We found that despite the many possible genetic and environmental exposure differences in infants across 4 continents, innate cytokine responses were similar for infants from North America, South America, and Europe. However, cells from South African infants secreted significantly lower levels of cytokines than did cells from infants from the 3 other sites, and did so following stimulation of extracellular and endosomal but not cytosolic PRRs.

Conclusions

Substantial differences in innate cytokine responses to PRR stimulation exist among different populations of infants that could not have been predicted. Delineating the underlying mechanism(s) for these differences will not only aid in improving vaccine-mediated protection but possibly also provide clues for the susceptibility to infection in different regions of the world.

Item Type:	Article
Subjects:	QU Biochemistry > Genetics > QU 450 General Works QW Microbiology and Immunology > Immunity by Type > QW 541 Natural immunity. Immunogenetics QW Microbiology and Immunology > Immunity by Type > QW 568 Cellular immunity. Immunologic cytotoxicity. Immunocompetence. Immunologic factors (General) QW Microbiology and Immunology > Immunotherapy and Hypersensitivity > QW 805 Vaccines. Antitoxins. Toxoids
Faculty: Department:	Biological Sciences > Department of Tropical Disease Biology
Digital Object Identifer (DOI):	https://doi.org/10.1016/j.jaci.2013.09.038
Depositing User:	Lynn Roberts-Maloney
Date Deposited:	24 Apr 2015 09:58
Last Modified:	06 Feb 2018 13:09
URI:	https://archive.lstmed.ac.uk/id/eprint/5109

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