Foth, Bernardo J, Tsai, Isheng J, Reid, Adam J, Bancroft, Allison J, Nichol, Sarah, Tracey, Alan, Holroyd, Nancy, Cotton, James A, Stanley, Eleanor J, Zarowiecki, Magdalena, Liu, Jimmy Z, Huckvale, Thomas, Cooper, Philip, Grencis, Richard K and Berriman, Matthew (2014) 'Whipworm genome and dual-species transcriptome analyses provide molecular insights into an intimate host-parasite interaction'. Nature Genetics, Vol 46, Issue 7, pp. 693-700.
|
Text
Nature_Genetics_46_693-700.pdf - Published Version Available under License Creative Commons Attribution Non-commercial Share Alike. Download (792kB) |
Abstract
Whipworms are common soil-transmitted helminths that cause debilitating chronic infections in man. These nematodes are only distantly related to Caenorhabditis elegans and have evolved to occupy an unusual niche, tunneling through epithelial cells of the large intestine. We report here the whole-genome sequences of the human-infective Trichuris trichiura and the mouse laboratory model Trichuris muris. On the basis of whole-transcriptome analyses, we identify many genes that are expressed in a sex- or life stage–specific manner and characterize the transcriptional landscape of a morphological region with unique biological adaptations, namely, bacillary band and stichosome, found only in whipworms and related parasites. Using RNA sequencing data from whipworm-infected mice, we describe the regulated T helper 1 (TH1)-like immune response of the chronically infected cecum in unprecedented detail. In silico screening identified numerous new potential drug targets against trichuriasis. Together, these genomes and associated functional data elucidate key aspects of the molecular host-parasite interactions that define chronic whipworm infection.
Item Type: | Article |
---|---|
Subjects: | QU Biochemistry > Genetics > QU 460 Genomics. Proteomics QU Biochemistry > Proteins. Amino Acids. Peptides > QU 58.7 RNA QX Parasitology > Helminths. Annelida > QX 200 Helminths QX Parasitology > Helminths. Annelida > QX 203 Nematoda QX Parasitology > QX 45 Host-parasite relations WC Communicable Diseases > Tropical and Parasitic Diseases > WC 698 Parasitic intestinal diseases (General) |
Faculty: Department: | Biological Sciences > Department of Tropical Disease Biology |
Digital Object Identifer (DOI): | https://doi.org/10.1038/ng.3010 |
Depositing User: | Lynn Roberts-Maloney |
Date Deposited: | 15 May 2015 14:18 |
Last Modified: | 06 Feb 2018 13:09 |
URI: | https://archive.lstmed.ac.uk/id/eprint/5148 |
Statistics
Actions (login required)
Edit Item |