O'Neill, Paul M and Ward, Steve ORCID: https://orcid.org/0000-0003-2331-3192 (2015) 'A Quinoline Carboxamide Antimalarial Drug Candidate Uniquely Targets Plasmodia at Three Stages of the Parasite Life Cycle'. Angewandte Chemie (International ed. in English), Vol 54, Issue 46, pp. 13504-6.
Full text not available from this repository.Abstract
Putting a stop to malaria: Phenotypic screening against malaria parasites, hit identification, and efficient lead optimization have delivered the preclinical candidate antimalarial DDD107498. This molecule is distinctive in that it has potential for use as a single-dose cure for malaria and shows a unique broad spectrum of activity against the liver, blood, and mosquito stages of the parasite life cycle.
Item Type: | Article |
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Uncontrolled Keywords: | antimalarials; drug discovery; inhibitors; lead-optimization; medicinal chemistry |
Subjects: | QV Pharmacology > Anti-Inflammatory Agents. Anti-Infective Agents. Antineoplastic Agents > QV 256 Antimalarials QV Pharmacology > Drug Standardization. Pharmacognosy. Medicinal Plants > QV 744 Pharmaceutical chemistry QX Parasitology > Protozoa > QX 135 Plasmodia WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria |
Faculty: Department: | Biological Sciences > Department of Tropical Disease Biology |
Digital Object Identifer (DOI): | https://doi.org/10.1002/anie.201507264 |
Depositing User: | Mary Creegan |
Date Deposited: | 27 Jan 2016 15:12 |
Last Modified: | 14 Dec 2021 10:53 |
URI: | https://archive.lstmed.ac.uk/id/eprint/5418 |
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