Tools
Tools
Burger, Renee J., vanEijk, Anna 
ORCID: https://orcid.org/0000-0003-1635-1289, Bussink, Milena, Hill, Jenny ORCID: https://orcid.org/0000-0003-1588-485X and terKuile, Feiko ORCID: https://orcid.org/0000-0003-3663-5617
(2016)
'Artemisinin-Based Combination Therapy Versus Quinine
or Other Combinations for Treatment of Uncomplicated
Plasmodium falciparum Malaria in the Second and
Third Trimester of Pregnancy: A Systematic Review and
Meta-Analysis'. Open Forum Infectious Diseases, Vol 3, Issue 1.
|
Text
ofv170.pdf - Published Version Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (842kB) | Preview |
Abstract
The World Health Organization recommends artemisinin-based combination therapies (ACTs) for the treatment of uncomplicated falciparum malaria in the second and third trimesters of pregnancy. We conducted a meta-analysis to compare efficacy, safety and tolerability of ACTs versus quinine and other non-ACT antimalarials. The median PCR-adjusted failure rate by days 28 to 63 in the non-ACT group was 6 (range 0–37) per 100 women, lower in the ACT group overall (pooled risk ratio [PRR] random effects, 0.41; 95% confidence interval [CI], 0.16–1.05; 6 trials), and significantly lower compared with oral quinine (PRR, 0.20; 95% CI, 0.08–0.49; 4 trials). There were no differences in fetal deaths and congenital abnormalities. Compared with quinine, artemisinin-based combinations therapies were associated with less tinnitus (PRR, 0.19; 95% CI, 0.03–1.11; 4 studies), dizziness (PRR, 0.64; 95% CI, 0.44–0.93; 3 trials), and vomiting (PRR, 0.33; 95% CI, 0.15–0.73; 3 trials). Artemisinin-based combination therapies are better than quinine in the second and third trimesters; their use should be encouraged among health workers.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Treatment; Artemisinins; Malaria; Pregnancy; Quinine |
| Subjects: | WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria WC Communicable Diseases > Tropical and Parasitic Diseases > WC 770 Therapy WQ Obstetrics > Pregnancy Complications > WQ 256 Infectious diseases |
| Faculty: Department: | Clinical Sciences & International Health > Clinical Sciences Department |
| Digital Object Identifer (DOI): | https://doi.org/10.1093/ofid/ofv170 |
| Depositing User: | Jacqueline Pearce |
| Date Deposited: | 22 Jan 2016 12:15 |
| Last Modified: | 16 Aug 2019 13:40 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/5528 |
Statistics
Actions (login required)
 |
Edit Item |