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Lewis, Joseph 
ORCID: https://orcid.org/0000-0002-3837-5188, MacPherson, Peter ORCID: https://orcid.org/0000-0002-0329-9613, Adams, Emily ORCID: https://orcid.org/0000-0002-0816-2835, Ochodo, Eleanor, Sands, Anita and Taegtmeyer, Miriam ORCID: https://orcid.org/0000-0002-5377-2536
(2015)
'Field accuracy of fourth-generation rapid diagnostic tests for acute HIV-1: a systematic review.'. AIDS, Vol 29, Issue 18, pp. 2465-2471.
Abstract
INTRODUCTION
Fourth-generation HIV-1 rapid diagnostic tests (RDTs) detect HIV-1 p24 antigen to screen for acute HIV-1. However, diagnostic accuracy during clinical use may be suboptimal.
METHODS
Clinical sensitivity and specificity of fourth-generation RDTs for acute HIV-1 were collated from field evaluation studies in adults identified by a systematic literature search.
RESULTS
Four studies with 17 381 participants from Australia, Swaziland, the United Kingdom and Malawi were identified. All reported 0% sensitivity of the HIV-1 p24 component for acute HIV-1 diagnosis; 26 acute infections were missed. Specificity ranged from 98.3 to 99.9%.
CONCLUSION
Fourth-generation RDTs are currently unsuitable for the detection of acute HIV-1.
| Item Type: | Article |
|---|---|
| Subjects: | WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503 Acquired immunodeficiency syndrome. HIV infections WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503.1 Diagnosis |
| Faculty: Department: | Biological Sciences > Department of Tropical Disease Biology Clinical Sciences & International Health > International Public Health Department |
| Digital Object Identifer (DOI): | https://doi.org/10.1097/QAD.0000000000000855 |
| Depositing User: | Mary Creegan |
| Date Deposited: | 19 Feb 2016 10:09 |
| Last Modified: | 14 Dec 2021 14:47 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/5671 |
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