van den Bogaart, E, de Bes, H M, Balraadjsing, P P S, Mens, P F, Adams, Emily ORCID: https://orcid.org/0000-0002-0816-2835, Grobusch, M P, van Die, I and Schallig, H D F H (2015) 'Leishmania donovani infection drives the priming of human monocyte-derived dendritic cells during Plasmodium falciparum co-infections.'. Parasite immunology, Vol 37, Issue 9, pp. 453-469.
Full text not available from this repository.Abstract
Functional impairment of dendritic cells (DCs) is part of a survival strategy evolved by Leishmania and Plasmodium parasites to evade host immune responses. Here, the effects of co-exposing human monocyte-derived DCs to Leishmania donovani promastigotes and Plasmodium falciparum-infected erythrocytes were investigated. Co-stimulation resulted in a dual, dose-dependent effect on DC differentiation which ranged from semi-mature cells, secreting low interleukin(-12p70 levels to a complete lack of phenotypic maturation in the presence of high parasite amounts. The effect was mainly triggered by the Leishmania parasites, as illustrated by their ability to induce semi-mature, interleukin-10-producing DCs, that poorly responded to lipopolysaccharide stimulation. Conversely, P. falciparum blood-stage forms failed to activate DCs and only slightly interfered with lipopolysaccharide effects. Stimulation with high L. donovani concentrations triggered phosphatidylserine translocation, whose onset presented after initiating the maturation impairment process. When added in combination, the two parasites could co-localize in the same DCs, confirming that the leading effects of Leishmania over Plasmodium may not be due to mutual exclusion. Altogether, these results suggest that in the presence of visceral leishmaniasis-malaria co-infections, Leishmania-driven effects may overrule the more silent response elicited by P. falciparum, shaping host immunity towards a regulatory pattern and possibly delaying disease resolution.
Item Type: | Article |
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Uncontrolled Keywords: | co-infection; dendritic cell; Leishmania donovani; Plasmodium falciparum |
Subjects: | QX Parasitology > Protozoa > QX 135 Plasmodia QX Parasitology > Protozoa > QX 70 Mastigophora. (e.g., Giardia. Trichomonas. Trypanosoma. Leishmania) WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria |
Faculty: Department: | Biological Sciences > Department of Tropical Disease Biology |
Digital Object Identifer (DOI): | https://doi.org/10.1111/pim.12214 |
Depositing User: | Mary Creegan |
Date Deposited: | 19 Feb 2016 10:14 |
Last Modified: | 15 Jun 2018 10:26 |
URI: | https://archive.lstmed.ac.uk/id/eprint/5673 |
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