Persistently Elevated C-Reactive Protein Level in the First Year of Antiretroviral Therapy, Despite Virologic Suppression, Is Associated With HIV Disease Progression in Resource-Constrained Settings.

Shivakoti, Rupak, Yang, Wei-Teng, Berendes, Sima, Mwelase, Noluthando, Kanyama, Cecilia, Pillay, Sandy, Samaneka, Wadzanai, Santos, Breno, Poongulali, Selvamuthu, Tripathy, Srikanth, Riviere, Cynthia, Lama, Javier R, Cardoso, Sandra W, Sugandhavesa, Patcharaphan, Balagopal, Ashwin, Gupte, Nikhil, Semba, Richard D, Campbell, Thomas B, Bollinger, Robert C and Gupta, Amita (2016) 'Persistently Elevated C-Reactive Protein Level in the First Year of Antiretroviral Therapy, Despite Virologic Suppression, Is Associated With HIV Disease Progression in Resource-Constrained Settings.'. Journal of Infectious Disease, Vol 213, Issue 7, pp. 1074-8.

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Abstract

A case-cohort analysis of human immunodeficiency virus (HIV)-infected individuals receiving antiretroviral therapy (ART) was performed within a multicountry randomized trial (PEARLS) to assess the prevalence of persistently elevated C-reactive protein (CRP) levels, based on serial measurements of CRP levels, and their association with HIV clinical failure. A persistently elevated CRP level in plasma (defined as ≥ 5 mg/L at both baseline and 24 weeks after ART initiation) was observed in 50 of 205 individuals (24%). A persistently elevated CRP level but not an elevated CRP level only at a single time point was independently associated with increased clinical failure, compared with a persistently low CRP level, despite achievement of virologic suppression. Serial monitoring of CRP levels could identify individuals who are at highest risk of HIV progression and may benefit from future adjunct antiinflammatory therapies.

Item Type:	Article
Subjects:	QZ Pathology > Manifestations of Disease > QZ 140 General manifestations of disease > QZ 150 Local reactions to injury and disease WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503 Acquired immunodeficiency syndrome. HIV infections WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503.2 Therapy
Faculty: Department:	Clinical Sciences & International Health > International Public Health Department
Digital Object Identifer (DOI):	https://doi.org/10.1093/infdis/jiv573
Depositing User:	Helen Fletcher
Date Deposited:	16 Mar 2016 14:51
Last Modified:	07 Dec 2018 10:16
URI:	https://archive.lstmed.ac.uk/id/eprint/5780

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