LSTM Home > LSTM Research > LSTM Online Archive

GeneXpert MTB/Rif to Diagnose Tuberculous Meningitis: Perhaps the First Test but not the Last

Tools

Bahr, Nathan C, Marais, Suzaan, Caws, Maxine ORCID: https://orcid.org/0000-0002-9109-350X, van Crevel, Reinout, Wilkinson, Robert J, Tyagi, Jaya S, Thwaites, Guy E and Boulware, David R (2016) 'GeneXpert MTB/Rif to Diagnose Tuberculous Meningitis: Perhaps the First Test but not the Last'. Clinical Infectious Diseases, Vol 62, Issue 9, pp. 1133-1135.

Full text not available from this repository.

Official URL: http://cid.oxfordjournals.org/content/62/9/1133

Abstract

Tuberculous meningitis (TBM) is the most severe form of tuberculosis with substantial mortality. In May 2015, 54 researchers from 10 countries met in Da Lat, Vietnam, to discuss advances in TBM. Among the attendees were researchers involved in pivotal studies on the use of Xpert MTB/Rif for TBM diagnosis. Attendees discussed the 2014 World Health Organization strong recommendation favoring the use of Xpert “in preference to conventional microscopy and culture as the initial diagnostic test for cerebrospinal fluid (CSF) if the sample volume is low or if additional specimens cannot be obtained to make a quick diagnosis.” Attendees were concerned that the limitations of Xpert testing for TBM are not emphasized. Clear guidance is needed for the investigational pathway for TBM, including recommendations on the diagnostic package of investigations, which does not stop with Xpert testing. Second, emphasis on the large CSF volumes (ideally 8–10 mL) needed for Xpert testing is required. Guidelines should also emphasize that TBM is a medical emergency and early treatment reduces mortality.

Item Type:	Article
Corporate Authors:	Tuberculous Meningitis International Research Consortium
Subjects:	WF Respiratory System > Tuberculosis > WF 200 Tuberculosis (General) WF Respiratory System > Tuberculosis > WF 220 Diagnosis. Prognosis WL Nervous System > WL 200 Meninges. Blood-brain barrier
Faculty: Department:	Clinical Sciences & International Health > Clinical Sciences Department Clinical Sciences & International Health > International Public Health Department
Digital Object Identifer (DOI):	https://doi.org/10.1093/cid/ciw083
Depositing User:	Jessica Jones
Date Deposited:	22 Mar 2016 12:45
Last Modified:	15 Jun 2018 14:52
URI:	https://archive.lstmed.ac.uk/id/eprint/5794

Statistics

View details

Actions (login required)

Edit Item