Plasmodium falciparum Icam-1-based cytoadherence-related signalling in endothelical cells

Jenkins, N., Wu, Yang, Chakravorty, S., Kai, O., Marsh, Kevin and Craig, Alister (2008) 'Plasmodium falciparum Icam-1-based cytoadherence-related signalling in endothelical cells'. Journal of Infection, Vol 56, Issue 4, p. 299.

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Abstract

Background: Cytoadherence of Plasmodium falciparum infected erythrocytes to host endothelium has been associated with pathology in severe malaria, but despite extensive information on the primary processes involved in the adhesive interactions the mechanisms underlying disease are poorly understood. There is evidence that during cerebral malaria there is subtle, focal alteration in the integrity of the blood-brain barrier. Rather than being passive bystanders, we have considered how endothelial cells might respond to parasite binding with direct effects on barrier function.

Item Type:	Article
Subjects:	QX Parasitology > Protozoa > QX 135 Plasmodia WC Communicable Diseases > Tropical and Parasitic Diseases > WC 755.1 General coverage
Faculty: Department:	Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI):	https://doi.org/10.1016/j.jinf.2008.01.018
Depositing User:	Mary Creegan
Date Deposited:	23 Aug 2010 10:46
Last Modified:	06 Feb 2018 13:00
URI:	https://archive.lstmed.ac.uk/id/eprint/817

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