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Hubbard, Alasdair 
ORCID: https://orcid.org/0000-0001-6668-9179, Davies, Sian, Baxter, Laura, Thompson, Sarah, Collery, Mark, Hand, Daniel, Thomas, Daniel John and Fink, Colin
(2018)
'Comparison of the first whole genome sequence of ‘Haemophilus quentini’ with two new strains of ‘Haemophilus quentini’ and other Haemophilus species'. Genome, Vol 61, Issue 5, pp. 379-385.
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genome_comparison of the first whole genome sequence of Haemophilios quentini.pdf - Accepted Version Download (1MB) | Preview |
Abstract
Comparison of the genome of the Gram negative human pathogen Haemophilus quentini MP1 with other Haemophilus species revealed that, although it is more closely related to Haemophilus haemolyticus than Haemophilus influenzae, the pathogen is in fact genetically distinct, a finding confirmed by phylogenetic analysis using the H. influenzae multilocus sequence typing genes. Further comparison with two other H. quentini strains recently identified in Canada revealed that these three genomes are more closely related than any other Haemophilus species, however there is still some sequence variation. There was no evidence of acquired antimicrobial resistance within the H. quentini MP1 genome nor any mutations within the DNA gyrase or topoisomerase IV genes known to confer resistance to fluoroquinolones, which has been previously identified in other H. quentini isolates. We hope by presenting the annotation and genetic comparison of the H. quentini MP1 genome it will aid the future molecular detection of this potentially emerging pathogen via the identification of unique genes that differentiate it from other Haemophilus species.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NOT_LSTM |
| Subjects: | QU Biochemistry > QU 4 General works QU Biochemistry > Genetics > QU 450 General Works QU Biochemistry > Genetics > QU 460 Genomics. Proteomics QU Biochemistry > Genetics > QU 470 Genetic structures |
| Faculty: Department: | Biological Sciences > Department of Tropical Disease Biology |
| Digital Object Identifer (DOI): | https://doi.org/10.1139/gen-2017-0195 |
| SWORD Depositor: | JISC Pubrouter |
| Depositing User: | Stacy Murtagh |
| Date Deposited: | 22 Mar 2018 12:08 |
| Last Modified: | 05 Nov 2024 08:44 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/8375 |
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