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Njenga, S. M., Wamae, C. N., Njomo, D. W., Mwandawiro, C. S. and Molyneux, David 
ORCID: https://orcid.org/0000-0001-8537-7947
(2008)
'Impact of two rounds of mass treatment with diethylcarbamazine plus albendazole on Wuchereria bancrofti infection and the sensitivity of immunochromatographic test in Malindi, Kenya'. Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol 102, Issue 10, pp. 1017-1024.
Abstract
Annual single-dose mass treatment of endemic populations with a combination of either diethylcarbamazine (DEC) or ivermectin plus albendazole is recommended as the mainstay of lymphatic filariasis elimination programmes. We evaluated the impact of two rounds of annual mass drug administration (MDA) of DEC and albendazole on bancroftian filariasis in a pilot elimination programme in an endemic area of Kenya. Overall prevalence of microfilaraemia decreased by 65.4%, whereas community microfilarial load decreased by 84% after the two MDAs. The prevalence of parasite antigenaemia determined by immunochromatographic test (ICT) declined significantly by 43.5% after the two MDAs. We also studied the effect of mass treatment on the sensitivity of the ICT. Although the sensitivity of the test before treatment was high (89.9%; K =0.909) sensitivity was lower after two MDAs (59.3%; K = 0.644). The finding raises concern about the reliability of the ICT in long-term monitoring of infection and for establishing programmatic endpoints. The results of the present study indicate a relatively high effectiveness of MDA using a DEC/albendazole combination against Wuchereria bancrofti infection and, therefore, it may be a useful strategy to eliminate lymphatic filariasis in onchocerciasis-free areas. (c) 2008 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | lymphatic filariasis wuchereria bancrofti mass drug administration diethylcarbamazine albendazole kenya eliminate lymphatic filariasis global program efficacy microfilaremia onchocerciasis chemotherapy antigenemia strategies |
| Subjects: | QX Parasitology > Helminths. Annelida > QX 301 Filarioidea WC Communicable Diseases > Tropical and Parasitic Diseases > WC 880 Filariasis and related conditions (General) |
| Faculty: Department: | Groups (2002 - 2012) > Disease Control Strategy Group |
| Digital Object Identifer (DOI): | https://doi.org/10.1016/j.trstmh.2008.04.039 |
| Depositing User: | Ms Julia Martin |
| Date Deposited: | 08 Nov 2010 10:47 |
| Last Modified: | 06 Feb 2018 13:00 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/882 |
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