A model for venom-induced consumptive coagulopathy in snake bite

Tanos, P. P., Isbister, G. K., Lalloo, David ORCID: https://orcid.org/0000-0001-7680-2200, Kirkpatrick, C. M. J. and Duffull, S. B. (2008) 'A model for venom-induced consumptive coagulopathy in snake bite'. Toxicon, Vol 52, Issue 7, pp. 769-780.

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Abstract

Many snake venoms contain procoagulant toxins that activate the coagulation cascade and cause venom-induced consumptive coagulopathy (VICC). We developed a semi-mechanistic model of the clotting cascade in order to explore the effects of the procoagulant toxin from taipan venom on this system as well as the effects of antivenom. Simulations of the time course in the change of clotting factors were compared to data collected from taipan envenomed patients. The model accurately predicted the observed concentration of clotting factors over time following taipan envenomation. Investigations from the model indicated that the upper limit of the half-life of the procoagulant toxin was I h. Simulations from the model also suggest that antivenom for Australasian elapids has negligible effect on reducing the recovery time of the coagulation profile unless administered almost immediately after envenomation. The model has generality to be expanded to describe the effects of other venoms and drugs on the clotting cascade. (C) 2008 Elsevier Ltd. All rights reserved

Item Type:	Article
Uncontrolled Keywords:	antivenom; coagulation cascade; coagulopathy; procoagulant; toxin; pkpd; taipan; activated protein-c; blood-coagulation; prothrombin activator; mathematical-model; factor va; factor-xi; factor-xa; complex; thrombin; kinetics
Subjects:	QW Microbiology and Immunology > Antigens and Antibodies. Toxins and Antitoxins > QW 630 Toxins. Antitoxins WD Disorders of Systemic, Metabolic or Environmental Origin, etc > Animal Poisons > WD 410 Reptiles
Faculty: Department:	Groups (2002 - 2012) > Clinical Group
Digital Object Identifer (DOI):	https://doi.org/10.1016/j.toxicon.2008.08.013
Depositing User:	Users 43 not found.
Date Deposited:	15 Jul 2010 14:45
Last Modified:	06 Feb 2018 13:00
URI:	https://archive.lstmed.ac.uk/id/eprint/931

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