Plasma Folate Level and High-Dose Folate Supplementation Predict Sulfadoxine-Pyrimethamine Treatment Failure in Pregnant Women in Western Kenya Who Have Uncomplicated Malaria

van Eijk, Anna, Ouma, P. O., Williamson, J., terKuile, Feiko ORCID: https://orcid.org/0000-0003-3663-5617, Parise, M., Otieno, K., Hamel, M. J., Ayisi, J. G., Kariuki, S., Kager, P. A. and Slutsker, L. (2008) 'Plasma Folate Level and High-Dose Folate Supplementation Predict Sulfadoxine-Pyrimethamine Treatment Failure in Pregnant Women in Western Kenya Who Have Uncomplicated Malaria'. Journal of Infectious Disease, Vol 198, Issue 10, pp. 1550-1553.

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Abstract

Sulfadoxine-pyrimethamine (SP) inhibits folate metabolism by the malaria parasite. We investigated the association between folate levels and SP failure in pregnant women. Data from a trial to assess the effect that folate supplementation has on SP failure in 467 pregnant women were analyzed. Plasmafolate levels were determined at enrollment and at day 7. High baseline folate levels, high parasite densities, and age <20 years were risk factors for SP failure. High-dose (5 mg daily) folate supplementation or high folate levels at day 7 were independent risk factors. Therefore, pregnant women receiving SP should receive low-/moderate-dose folate supplementation.

Item Type:	Article
Subjects:	WQ Obstetrics > Pregnancy Complications > WQ 240 Pregnancy complications (General) QX Parasitology > Protozoa > QX 135 Plasmodia WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria QX Parasitology > QX 45 Host-parasite relations QX Parasitology > Insects. Other Parasites > QX 650 Insect vectors
Digital Object Identifer (DOI):	https://doi.org/10.1086/592715
Related URLs:	http://www.mip-consortium.org
Depositing User:	Helen Wong
Date Deposited:	16 Jun 2010 15:19
Last Modified:	07 Dec 2018 09:46
URI:	https://archive.lstmed.ac.uk/id/eprint/940

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