Global expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation

Brynildsrud, Ola B., Pepperell, Caitlin S., Suffys, Philip, Grandjean, Louis, Monteserin, Johana, Debech, Nadia, Bohlin, Jon, Alfsnes, Kristian, Pettersson, John O.-H., Kirkeleite, Ingerid, Fandinho, Fatima, da Silva, Marcia Aparecida, Perdigao, Joao, Portugal, Isabel, Viveiros, Miguel, Clark, Taane, Caws, Maxine ORCID: https://orcid.org/0000-0002-9109-350X, Dunstan, Sarah, Thai, Phan Vuong Khac, Lopez, Beatriz, Ritacco, Viviana, Kitchen, Andrew, Brown, Tyler S., van Soolingen, Dick, O’Neill, Mary B., Holt, Kathryn E., Feil, Edward J., Mathema, Barun, Balloux, Francois and Eldholm, Vegard (2018) 'Global expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation'. Science Advances, Vol 4, Issue 10, eaat5869.

Preview

Text science L4 article_accepted version - Max Caws.pdf - Published Version Available under License Creative Commons Attribution Non-commercial. Download (6MB) | Preview

Abstract

On the basis of population genomic and phylogeographic analyses of 1669 Mycobacterium tuberculosis lineage 4 (L4) genomes, we find that dispersal of L4 has been completely dominated by historical migrations out of Europe. We demonstrate an intimate temporal relationship between European colonial expansion into Africa and the Americas and the spread of L4 tuberculosis (TB). Markedly, in the age of antibiotics, mutations conferring antimicrobial resistance overwhelmingly emerged locally (at the level of nations), with minimal cross-border transmission of resistance. The latter finding was found to reflect the relatively recent emergence of these mutations, as a similar degree of local restriction was observed for susceptible variants emerging on comparable time scales. The restricted international transmission of drug-resistant TB suggests that containment efforts at the level of individual countries could be successful.

Item Type:	Article
Subjects:	QW Microbiology and Immunology > Bacteria > QW 125 Actinibacteria, Actinomycetales. WC Communicable Diseases > Infection. Bacterial Infections > Other Bacterial Infections. Zoonotic Bacterial Infections > WC 302 Actinomycetales infections. Mycobacterium infections WF Respiratory System > Tuberculosis > WF 200 Tuberculosis (General)
Faculty: Department:	Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):	https://doi.org/10.1126/sciadv.aat5869
Depositing User:	Stacy Murtagh
Date Deposited:	24 Oct 2018 13:45
Last Modified:	03 Aug 2021 13:59
URI:	https://archive.lstmed.ac.uk/id/eprint/9496

Statistics

View details

Actions (login required)

Edit Item