Safety and effectiveness of apheresis in the treatment of infectious diseases: A systematic review

Odedra, Anand, Lalloo, David ORCID: https://orcid.org/0000-0001-7680-2200, Kennedy, Glen, Llewellyn, Stacey and McCarthy, James (2019) 'Safety and effectiveness of apheresis in the treatment of infectious diseases: A systematic review'. Journal of Infection, Vol 79, Issue 6, pp. 513-520.

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Abstract

Objectives: Apheresis has been used as adjunctive treatment of severe falciparum malaria, loiasis and babesiosis. This systematic review aimed to investigate the safety and efficacy of apheresis in the treat- ment of these conditions. Methods: MEDLINE, PUBMED, EMBASE and CINAHL databases were searched to identify studies published between January 1969 and March 2018 involving patients treated using apheresis for severe falciparum malaria, loiasis or babesiosis. Data extracted included details about the apheresis intervention, popula- tions, study methods and outcomes relating to efficacy and safety. Results: A total of 67 publications met the inclusion criteria and were included in the data synthesis, 36 for malaria (70 cases), 17 for babesiosis (22 cases) and 14 for loiasis (34 cases). Publications were case reports, case series, and cohort studies; there were no randomised controlled trials identified. Potential publication bias was considered to be high. Conclusions: Systematic review of the literature suggests that apheresis may be a useful adjunct in the treatment of patients hospitalised for babesiosis, and prior to chemotherapy in loiasis with microfilarial count > 80 0 0 parasites/mL. Data does not support the use of apheresis in patients with severe falciparum malaria.

Item Type:	Article
Subjects:	WA Public Health > Statistics. Surveys > WA 900 Public health statistics WA Public Health > Statistics. Surveys > WA 950 Theory or methods of medical statistics. Epidemiologic methods WC Communicable Diseases > WC 20 Research (General) WH Hemic and Lymphatic Systems > Hematologic Diseases. Immunologic Factors. Blood Banks > WH 460 Blood bank procedures
Faculty: Department:	Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):	https://doi.org/10.1016/j.jinf.2019.09.014
Depositing User:	Annmarie Hand
Date Deposited:	16 Dec 2019 13:17
Last Modified:	14 Oct 2020 01:02
URI:	https://archive.lstmed.ac.uk/id/eprint/13337

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