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Kalizang’oma, Akuzike, Richard, Damien, Kwambana, Brenda, Coelho, Juliana, Broughton, Karen, Pichon, Bruno, Hopkins, Katie L., Chalker, Victoria, Beleza, Sandra, Bentley, Stephen D., Chaguza, Chrispin and Heyderman, Robert S. (2024) 'Population genomics of Streptococcus mitis in UK and Ireland bloodstream infection and infective endocarditis cases'. Nature Communications, Vol 15, Issue 1, p. 7812.
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Abstract
Streptococcus mitis is a leading cause of infective endocarditis (IE). However, our understanding of the genomic epidemiology and pathogenicity of IE-associated S. mitis is hampered by low IE incidence. Here we use whole genome sequencing of 129 S. mitis bloodstream infection (BSI) isolates collected between 2001–2016 from clinically diagnosed IE cases in the UK to investigate genetic diversity, antimicrobial resistance, and pathogenicity. We show high genetic diversity of IE-associated S. mitis with virtually all isolates belonging to distinct lineages indicating no predominance of specific lineages. Additionally, we find a highly variable distribution of known pneumococcal virulence genes among the isolates, some of which are overrepresented in disease when compared to carriage strains. Our findings suggest that S. mitis in patients with clinically diagnosed IE is not primarily caused by specific hypervirulent or antimicrobial resistant lineages, highlighting the accidental pathogenic nature of S. mitis in patients with clinically diagnosed IE.
| Item Type: | Article |
|---|---|
| Subjects: | QY Clinical Pathology > Blood. Blood Chemistry > QY 450 Blood chemistry WG Cardiovascular System > WG 120 Cardiovascular diseases |
| Faculty: Department: | Clinical Sciences & International Health > Malawi-Liverpool-Wellcome Programme (MLW) |
| Digital Object Identifer (DOI): | https://doi.org/10.1038/s41467-024-52120-z |
| SWORD Depositor: | JISC Pubrouter |
| Depositing User: | JISC Pubrouter |
| Date Deposited: | 26 Sep 2024 07:26 |
| Last Modified: | 26 Sep 2024 07:26 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/25296 |
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