Does IFN-γ play a role on the pathogenesis of non-atopic asthma in Latin America children?

Figueiredo, Camila Alexandrina, Rodrigues, Laura Cunha, Alcantara-Neves, Neuza Maria, Cooper, Philip, Amorim, Leila Denise, Silva, Nivea Bispo, Cruz, Alvaro A and Barreto, Mauricio Lima (2012) 'Does IFN-γ play a role on the pathogenesis of non-atopic asthma in Latin America children?'. Allergy, Asthma & Clinical Immunology, Vol 8, e18.

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Abstract

In this work we explore differences in blood cells and cytokine profiles in children according to atopic status and asthma (atopic or non-atopic). The study involved measurement of Th1(IFN-γ) and Th2 (IL-5 and IL-13) cytokines in Dermatophagoides pteronyssinus stimulated peripheral blood leukocytes, blood cell count, skin prick test and specific IgE against common aeroallergens. Atopic status was associated with eosinophilia and production of Th2 type cytokines. Atopic asthma was associated with eosinophilia and non-atopic asthma was associated with IFN-γ and elevated monocytes in blood. IFN-γ and monocytes might play a role in immunopathology of non-atopic asthma in Latin American children.

Item Type:	Article
Additional Information:	The electronic version of this article is the complete one and can be found online at: http://www.aacijournal.com/content/8/1/18
Subjects:	QU Biochemistry > Cells and Genetics > QU 350 Cellular structures QW Microbiology and Immunology > Immunity by Type > QW 568 Cellular immunity. Immunologic cytotoxicity. Immunocompetence. Immunologic factors (General) QY Clinical Pathology > Blood. Blood Chemistry > QY 450 Blood chemistry WS Pediatrics > Diseases of Children and Adolescents > By System > WS 280 Respiratory system
Faculty: Department:	Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI):	https://doi.org/10.1186/1710-1492-8-18
Depositing User:	Lynn Roberts-Maloney
Date Deposited:	09 Jan 2015 10:57
Last Modified:	06 Feb 2018 13:08
URI:	https://archive.lstmed.ac.uk/id/eprint/4715

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