A maleness gene in the malaria mosquito Anopheles gambiae.

Krzywinska, Elzbieta, Dennison, Nathan, Lycett, Gareth ORCID: https://orcid.org/0000-0002-2422-053X and Krzywinski, Jaroslaw (2016) 'A maleness gene in the malaria mosquito Anopheles gambiae.'. Science, Vol 353, Issue 6294, pp. 67-9.

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Abstract

The molecular pathways controlling gender are highly variable and have been identified in only a few nonmammalian model species. In many insects, maleness is conferred by a Y chromosome-linked M factor of unknown nature. We have isolated and characterized a gene, Yob, for the M factor in the malaria mosquito Anopheles gambiae Yob, activated at the beginning of zygotic transcription and expressed throughout a male's life, controls male-specific splicing of the doublesex gene. Silencing embryonic Yob expression is male-lethal, whereas ectopic embryonic delivery of Yob transcripts yields male-only broods. This female-killing property may be an invaluable tool for creation of conditional male-only transgenic Anopheles strains for malaria control programs.

Item Type:	Article
Subjects:	QS Anatomy > Embryology > QS 638 Sex determination (Genetics). Sex preselection QU Biochemistry > Genetics > QU 500 Genetic phenomena QX Parasitology > Insects. Other Parasites > QX 510 Mosquitoes QX Parasitology > Insects. Other Parasites > QX 515 Anopheles
Faculty: Department:	Biological Sciences > Vector Biology Department
Digital Object Identifer (DOI):	https://doi.org/10.1126/science.aaf5605
Depositing User:	Jessica Jones
Date Deposited:	04 Jul 2016 09:52
Last Modified:	22 Aug 2019 11:03
URI:	https://archive.lstmed.ac.uk/id/eprint/5963

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