Krzywinska, Elzbieta, Dennison, Nathan, Lycett, Gareth ORCID: https://orcid.org/0000-0002-2422-053X and Krzywinski, Jaroslaw (2016) 'A maleness gene in the malaria mosquito Anopheles gambiae.'. Science, Vol 353, Issue 6294, pp. 67-9.
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Abstract
The molecular pathways controlling gender are highly variable and have been identified in only a few nonmammalian model species. In many insects, maleness is conferred by a Y chromosome-linked M factor of unknown nature. We have isolated and characterized a gene, Yob, for the M factor in the malaria mosquito Anopheles gambiae Yob, activated at the beginning of zygotic transcription and expressed throughout a male's life, controls male-specific splicing of the doublesex gene. Silencing embryonic Yob expression is male-lethal, whereas ectopic embryonic delivery of Yob transcripts yields male-only broods. This female-killing property may be an invaluable tool for creation of conditional male-only transgenic Anopheles strains for malaria control programs.
Item Type: | Article |
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Subjects: | QS Anatomy > Embryology > QS 638 Sex determination (Genetics). Sex preselection QU Biochemistry > Genetics > QU 500 Genetic phenomena QX Parasitology > Insects. Other Parasites > QX 510 Mosquitoes QX Parasitology > Insects. Other Parasites > QX 515 Anopheles |
Faculty: Department: | Biological Sciences > Vector Biology Department |
Digital Object Identifer (DOI): | https://doi.org/10.1126/science.aaf5605 |
Depositing User: | Jessica Jones |
Date Deposited: | 04 Jul 2016 09:52 |
Last Modified: | 22 Aug 2019 11:03 |
URI: | https://archive.lstmed.ac.uk/id/eprint/5963 |
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