Protective effect of PCV vaccine against experimental pneumococcal challenge in adults is primarily mediated by controlling colonisation density.

German, E L, SolorzanoGonzalez, Carla, Sunny, S, Dunne, F, Gritzfeld, J F, Mitsi, Elena, Nikolaou, Elissavet, Hyder-Wright, A D, Collins, A M ORCID: https://orcid.org/0000-0002-4094-1572, Gordon, S B ORCID: https://orcid.org/0000-0001-6576-1116 and Ferreira, D M ORCID: https://orcid.org/0000-0002-0594-0902 (2019) 'Protective effect of PCV vaccine against experimental pneumococcal challenge in adults is primarily mediated by controlling colonisation density.'. Vaccine, Vol 37, Issue 30, pp. 3953-3956.

Text Protective effect of PCV vaccine - Esther German.docx - Accepted Version Available under License Creative Commons Attribution. Download (81kB)

Abstract

Widespread use of Pneumococcal Conjugate Vaccines (PCV) has reduced vaccine-type nasopharyngeal colonisation and invasive pneumococcal disease. In a double-blind, randomised controlled trial using the Experimental Human Pneumococcal Challenge (EHPC) model, PCV-13 (Prevenar-13) conferred 78% protection against colonisation acquisition and reduced bacterial intensity (AUC) as measured by classical culture. We used a multiplex qPCR assay targeting lytA and pneumococcal serotype 6A/B cpsA genes to re-assess the colonisation status of the same volunteers. Increase in detection of low-density colonisation resulted in reduced PCV efficacy against colonisation acquisition (29%), compared to classical culture (83%). For experimentally colonised volunteers, PCV had a pronounced effect on decreasing colonisation density. These results obtained in adults suggest that the success of PCV vaccination could primarily be mediated by the control of colonisation density. Studies assessing the impact of pneumococcal vaccines should allow for density measurements in their design.

Item Type:	Article
Subjects:	QS Anatomy > QS 4 General works. Classify here works on regional anatomy QW Microbiology and Immunology > Immunotherapy and Hypersensitivity > QW 805 Vaccines. Antitoxins. Toxoids WB Practice of Medicine > WB 102 Clinical medicine WC Communicable Diseases > Infection. Bacterial Infections > Bacterial Infections > WC 217 Pneumococcal infections
Faculty: Department:	Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):	https://doi.org/10.1016/j.vaccine.2019.05.080
Depositing User:	Stacy Murtagh
Date Deposited:	12 Jun 2019 13:10
Last Modified:	05 Nov 2019 14:57
URI:	https://archive.lstmed.ac.uk/id/eprint/11026

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