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Auto-fluorescent PAMAM-based dendritic molecules and their potential application in pharmaceutical sciences

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El-Betany, Alaa M.M., Kamoun, Elbadawy A., James, Craig, Jangher, Abdulhakim, Aljayyoussi, Ghaith, Griffiths, Peter, McKeown, Neil B. and Gumbleton, Mark (2020) 'Auto-fluorescent PAMAM-based dendritic molecules and their potential application in pharmaceutical sciences'. International Journal of Pharmaceutics, Vol 579, p. 119187.

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Abstract

The epithelial permeation of water-soluble fluorescent PAMAM dendrons based on 7H-benz[de] benzimidazo [2,1-a] isoquinoline-7-one as a fluorescent core across epithelial cell models MDCK I and MDCK II has been quantified. Hydrodynamic radii have been derived from self-diffusion coefficients obtained via pulsed-gradient spin-echo Nuclear Magnetic Resonance (PGSE-NMR). Results indicate that these dendritic molecules are molecularly disperse, non-aggregating, and only slightly larger than their parent homologues. MDCK I permeability studies across epithelial barriers show that these dendritic molecules are biocompatible with the chosen epithelial in-vitro model and can permeate across MDCK cell monolayers. Permeability is demonstrated to be a property of dendritic size and cell barrier restrictiveness indicating that paracellular mechanisms play the predominant role in the transport of these molecules.

Item Type: Article
Subjects: WN Radiology. Diagnostic imaging > WN 100 General works. Stereoscopy. Electrokymography
WN Radiology. Diagnostic imaging > WN 180 Diagnostic imaging (General)
Faculty: Department: Biological Sciences > Department of Tropical Disease Biology
Digital Object Identifer (DOI): https://doi.org/10.1016/j.ijpharm.2020.119187
Depositing User: Stacy Murtagh
Date Deposited: 20 May 2020 11:17
Last Modified: 02 Mar 2021 02:02
URI: https://archive.lstmed.ac.uk/id/eprint/14469

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