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Probiotics reduce self-reported symptoms of upper respiratory tract infection in overweight and obese adults: should we be considering probiotics during viral pandemics?

Mullish, Benjamin H, Marchesi, Julian R, McDonald, Julie A K, Pass, Daniel A, Masetti, Giulia, Michael, Daryn R, Plummer, Sue, Jack, Alison A, Davies, Thomas S, Hughes, Timothy R and Wang, Duolao ORCID: https://orcid.org/0000-0003-2788-2464 (2021) 'Probiotics reduce self-reported symptoms of upper respiratory tract infection in overweight and obese adults: should we be considering probiotics during viral pandemics?'. Gut microbes, Vol 13, Issue 1, pp. 1-9.

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Abstract

Gut microbiome manipulation to alter the gut-lung axis may potentially protect humans against respiratory infections, and clinical trials of probiotics show promise in this regard in healthy adults and children. However, comparable studies are lacking in overweight/obese people, who have increased risks in particular of viral upper respiratory tract infections (URTI). This further analyses our recent placebo-controlled trial of probiotics in overweight/obese people (focused initially on weight loss) to investigate the impact of probiotics upon the occurrence of URTI symptoms. As well as undergoing loss of weight and improvement in certain metabolic parameters, study participants taking probiotics experienced a 27% reduction in URTI symptoms control, with those ≥45 years or BMI ≥30 kg/m experiencing greater reductions. This symptom reduction is apparent within 2 weeks of probiotic use. Gut microbiome diversity remained stable throughout the study in probiotic-treated participants. Our data provide support for further trials to assess the potential role of probiotics in preventing viral URTI (and possibly also COVID-19), particularly in overweight/obese people.

Item Type: Article
Subjects: QU Biochemistry > Vitamins > QU 145.5 Nutritive values of food
QW Microbiology and Immunology > QW 4 General works. Classify here works on microbiology as a whole.
WC Communicable Diseases > Virus Diseases > Viral Respiratory Tract Infections. Respirovirus Infections > WC 505 Viral respiratory tract infections
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI): https://doi.org/10.1080/19490976.2021.1900997
Depositing User: Julie Franco
Date Deposited: 13 Apr 2021 14:13
Last Modified: 13 Apr 2021 14:13
URI: https://archive.lstmed.ac.uk/id/eprint/17497

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