MicroRNA-29 specifies age-related differences in the CD8+ T cell immune response

Yee Mon, Kristel J., Zhu, Hongya, Daly, Ciarán W.P., Vu, Luyen T., Smith, Norah L., Patel, Ravi, Topham, David J., Scheible, Kristin, Jambo, Kondwani ORCID: https://orcid.org/0000-0002-3195-2210, Le, Minh T.N., Rudd, Brian D. and Grimson, Andrew (2021) 'MicroRNA-29 specifies age-related differences in the CD8+ T cell immune response'. Cell Reports, Vol 37, Issue 6, p. 109969.

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Abstract

MicroRNAs (miRNAs) have emerged as critical regulators of cell fate in the CD8+ T cell response to infection. Although there are several examples of miRNAs acting on effector CD8+ T cells after infection, it is unclear whether differential expression of one or more miRNAs in the naive state is consequential in altering their long-term trajectory. To answer this question, we examine the role of miR-29 in neonatal and adult CD8+ T cells, which express different amounts of miR-29 only prior to infection and adopt profoundly different fates after immune challenge. We find that manipulation of miR-29 expression in the naive state is sufficient for age-adjusting the phenotype and function of CD8+ T cells, including their regulatory landscapes and long-term differentiation trajectories after infection. Thus, miR-29 acts as a developmental switch by controlling the balance between a rapid effector response in neonates and the generation of long-lived memory in adults.

Item Type:	Article
Subjects:	QU Biochemistry > Proteins. Amino Acids. Peptides > QU 58.7 RNA QW Microbiology and Immunology > QW 4 General works. Classify here works on microbiology as a whole. WH Hemic and Lymphatic Systems > Hematologic Diseases. Immunologic Factors. Blood Banks > WH 200 Leukocytes. Leukocyte disorders (General)
Faculty: Department:	Clinical Sciences & International Health > Malawi-Liverpool-Wellcome Programme (MLW)
Digital Object Identifer (DOI):	https://doi.org/10.1016/j.celrep.2021.109969
Depositing User:	Stacy Murtagh
Date Deposited:	11 Nov 2021 11:14
Last Modified:	11 Nov 2021 11:14
URI:	https://archive.lstmed.ac.uk/id/eprint/19404

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