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Diniz, Mariana O, Mitsi, Elena, Swadling, Leo, Rylance, Jamie 
ORCID: https://orcid.org/0000-0002-2323-3611, Johnson, Marina, Goldblatt, David, Ferreira, Daniela ORCID: https://orcid.org/0000-0002-0594-0902 and Maini, Mala K
(2022)
'Airway-resident T cells from unexposed individuals cross-recognize SARS-CoV-2.'. Nature Immunology, Vol 23, Issue 9, pp. 1324-1329.
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PMC9477726.pdf - Published Version Available under License Creative Commons Attribution. Download (6MB) | Preview |
Abstract
T cells can contribute to clearance of respiratory viruses that cause acute-resolving infections such as SARS-CoV-2, helping to provide long-lived protection against disease. Recent studies have suggested an additional role for T cells in resisting overt infection: pre-existing cross-reactive responses were preferentially enriched in healthcare workers who had abortive infections<sup>1</sup>, and in household contacts protected from infection<sup>2</sup>. We hypothesize that such early viral control would require pre-existing cross-reactive memory T cells already resident at the site of infection; such airway-resident responses have been shown to be critical for mediating protection after intranasal vaccination in a murine model of SARS-CoV<sup>3</sup>. Bronchoalveolar lavage samples from the lower respiratory tract of healthy donors obtained before the COVID-19 pandemic revealed airway-resident, SARS-CoV-2-cross-reactive T cells, which correlated with the strength of human seasonal coronavirus immunity. We therefore demonstrate the potential to harness functional airway-resident SARS-CoV-2-reactive T cells in next-generation mucosal vaccines.
| Item Type: | Article |
|---|---|
| Subjects: | QU Biochemistry > Cells and Genetics > QU 350 Cellular structures WC Communicable Diseases > Virus Diseases > Viral Respiratory Tract Infections. Respirovirus Infections > WC 506 COVID-19 |
| Faculty: Department: | Clinical Sciences & International Health > Clinical Sciences Department |
| Digital Object Identifer (DOI): | https://doi.org/10.1038/s41590-022-01292-1 |
| SWORD Depositor: | JISC Pubrouter |
| Depositing User: | JISC Pubrouter |
| Date Deposited: | 13 Oct 2022 13:58 |
| Last Modified: | 13 Oct 2022 13:58 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/21236 |
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