Levels of DNA Adducts in the Blood and Follicular Fluid of Women Undergoing In Vitro Fertilization Treatment and Its Correlation with the Pregnancy Outcome

Al-Saleh, I., El-Doush, I., Arif, J., Coskun, S., Jaroudi, K., Al-Shahrani, A. and Mohamed, Gamal (2010) 'Levels of DNA Adducts in the Blood and Follicular Fluid of Women Undergoing In Vitro Fertilization Treatment and Its Correlation with the Pregnancy Outcome'. Bulletin of Environmental Contamination and Toxicology, Vol 84, Issue 1, pp. 23-28.

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Abstract

This study is designed to investigate the impact of DNA damage on pregnancy and fertilization rate outcome in a sub-sample of women undergoing IVF treatment. Blood and follicular fluid samples (n = 60) were analyzed for DNA adducts. While no BPDE-DNA adducts were detected, other unknown lipophilic adducts were seen in blood and follicular fluid. Women who failed to achieve pregnancy had higher DNA adducts in follicular fluid than those who succeeded (p < 0.05). Follicular fluid cotinine levels were associated with DNA adduct levels in blood and follicular fluid (p < 0.05). Evaluation of DNA damage resulting from oxidative stress could have a role in predicting IVF success rate. © 2009 Springer Science+Business Media, LLC.

Item Type:	Article
Additional Information:	The original publication is available at www.springerlink.com
Uncontrolled Keywords:	32P-Postlabeling technique DNA adducts Fertilization rate In vitro fertilization Pregnancy outcome Saudi Arabia
Subjects:	QU Biochemistry > Genetics > QU 450 General Works WP Gynecology > Anatomy. Diseases. Injuries > WP 565 Fertility WP Gynecology > Anatomy. Diseases. Injuries > WP 570 Infertility (General). Infertility in the female
Faculty: Department:	Groups (2002 - 2012) > Disease Control Strategy Group
Digital Object Identifer (DOI):	https://doi.org/10.1007/s00128-009-9889-z
Depositing User:	Tina Bowers
Date Deposited:	23 Jun 2010 14:08
Last Modified:	06 Feb 2018 12:59
URI:	https://archive.lstmed.ac.uk/id/eprint/218

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