Challenges and Approaches to Establishing Multi-Pathogen Serosurveillance: Findings from the 2023 Serosurveillance Summit

Carcelen, Andrea C., Kong, Alex C., Takahashi, Saki, Hegde, Sonia, Jaenisch, Thomas, Chu, May, Rochford, Rosemary, Kostandova, Natalya, Gurley, Emily S., Wesolowski, Amy, Azman, Andrew S., van der Klis, Fiona R. M., den Hartog, Gerco, Drakeley, Christopher, Heaney, Christopher, Winter, Amy K., Salje, Henrik, Rodriguez-Barraquer, Isabel, Leung, Daniel T., Njenga, Sammy M., Kagucia, Eunice Wangeci, Jambo, Kondwani ORCID: https://orcid.org/0000-0002-3195-2210, Wolter, Nicole, Charles, Richelle C., Saboyá-Díaz, Martha-Idalí, Martin, Diana L. and Moss, William J. (2024) 'Challenges and Approaches to Establishing Multi-Pathogen Serosurveillance: Findings from the 2023 Serosurveillance Summit'. American Journal of Tropical Medicine and Hygiene, Vol 11, Issue 5, pp. 1145-1152.

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Abstract

Multiplex-based serological surveillance is a valuable but underutilized tool to understand gaps in population-level exposure, susceptibility, and immunity to infectious diseases. Assays for which blood samples can be tested for antibodies against several pathogens simultaneously, such as multiplex bead immunoassays, can more efficiently integrate public health surveillance in low- and middle-income countries. On March 7–8, 2023 a group of experts representing research institutions, multilateral organizations, private industry, and country partners met to discuss experiences, identify challenges and solutions, and create a community of practice for integrated, multi-pathogen serosurveillance using multiplex bead assay technologies. Participants were divided into six working groups: 1) supply chain; 2) laboratory assays; 3) seroepidemiology; 4) data analytics; 5) sustainable implementation; and 6) use case scenarios. These working groups discussed experiences, challenges, solutions, and research needs to facilitate integrated, multi-pathogen serosurveillance for public health. Several solutions were proposed to address challenges that cut across working groups.

Item Type:	Article
Subjects:	QW Microbiology and Immunology > Antigens and Antibodies. Toxins and Antitoxins > QW 570 Serology. QZ Pathology > QZ 4 General works QZ Pathology > Pathogenesis. Etiology > QZ 40 Pathogenesis. Etiology
Faculty: Department:	Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):	https://doi.org/10.4269/ajtmh.24-0296
SWORD Depositor:	JISC Pubrouter
Depositing User:	JISC Pubrouter
Date Deposited:	02 Oct 2024 14:09
Last Modified:	18 Nov 2024 15:51
URI:	https://archive.lstmed.ac.uk/id/eprint/25327

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