Healthcare as a driver, reservoir and amplifier of antimicrobial resistance: opportunities for interventions

Cocker, Derek, Birgand, Gabriel, Zhu, Nina, Rodriguez-Manzano, Jesus, Ahmad, Raheelah, Jambo, Kondwani ORCID: https://orcid.org/0000-0002-3195-2210, Levin, Anna S. and Holmes, Alison (2024) 'Healthcare as a driver, reservoir and amplifier of antimicrobial resistance: opportunities for interventions'. Nature Reviews Microbiology, Vol 22, Issue 10, pp. 636-649.

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Abstract

Antimicrobial resistance (AMR) is a global health challenge that threatens humans, animals and the environment. Evidence is emerging for a role of healthcare infrastructure, environments and patient pathways in promoting and maintaining AMR via direct and indirect mechanisms. Advances in vaccination and monoclonal antibody therapies together with integrated surveillance, rapid diagnostics, targeted antimicrobial therapy and infection control measures offer opportunities to address healthcare-associated AMR risks more effectively. Additionally, innovations in artificial intelligence, data linkage and intelligent systems can be used to better predict and reduce AMR and improve healthcare resilience. In this Review, we examine the mechanisms by which healthcare functions as a driver, reservoir and amplifier of AMR, contextualized within a One Health framework. We also explore the opportunities and innovative solutions that can be used to combat AMR throughout the patient journey. We provide a perspective on the current evidence for the effectiveness of interventions designed to mitigate healthcare-associated AMR and promote healthcare resilience within high-income and resource-limited settings, as well as the challenges associated with their implementation.

Item Type:	Article
Subjects:	QW Microbiology and Immunology > QW 4 General works. Classify here works on microbiology as a whole. QW Microbiology and Immunology > QW 45 Microbial drug resistance. General or not elsewhere classified. WA Public Health > WA 20.5 Research (General)
Faculty: Department:	Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):	https://doi.org/10.1038/s41579-024-01076-4
Depositing User:	Lynn Roberts-Maloney
Date Deposited:	07 Oct 2024 15:12
Last Modified:	07 Oct 2024 15:13
URI:	https://archive.lstmed.ac.uk/id/eprint/25444

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