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Preston, Mark D., Campino, Susana, Assefa, Samuel A., Echeverry, Diego F., Ocholla, Harold, Amambua-Ngwa, Alfred, Stewart, Lindsay B., Conway, David J., Borrmann, Steffen, Michon, Pascal, Zongo, Issaka, Ouédraogo, Jean-Bosco, Djimde, Abdoulaye A., Doumbo, Ogobara K., Nosten, Francois, Pain, Arnab, Bousema, Teun, Drakeley, Chris J., Fairhurst, Rick M., Sutherland, Colin J., Roper, Cally and Clark, Taane G. (2014) 'A barcode of organellar genome polymorphisms identifies the geographic origin of Plasmodium falciparum strains'. Nature Communications, Vol 5, e4052.
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Abstract
Malaria is a major public health problem that is actively being addressed in a global eradication campaign. Increased population mobility through international air travel has elevated the risk of re-introducing parasites to elimination areas and dispersing drug-resistant parasites to new regions. A simple genetic marker that quickly and accurately identifies the geographic origin of infections would be a valuable public health tool for locating the source of imported outbreaks. Here we analyse the mitochondrion and apicoplast genomes of 711 Plasmodium falciparum isolates from 14 countries, and find evidence that they are non-recombining and co-inherited. The high degree of linkage produces a panel of relatively few single-nucleotide polymorphisms (SNPs) that is geographically informative. We design a 23-SNP barcode that is highly predictive (~92%) and easily adapted to aid case management in the field and survey parasite migration worldwide.
| Item Type: | Article |
|---|---|
| Subjects: | QU Biochemistry > Genetics > QU 460 Genomics. Proteomics QU Biochemistry > Genetics > QU 550 Genetic techniques. PCR. Chromosome mapping QX Parasitology > Protozoa > QX 135 Plasmodia WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria |
| Faculty: Department: | Biological Sciences > Department of Tropical Disease Biology |
| Digital Object Identifer (DOI): | https://doi.org/10.1038/ncomms5052 |
| Depositing User: | Lynn Roberts-Maloney |
| Date Deposited: | 14 Apr 2015 12:55 |
| Last Modified: | 06 Feb 2018 13:09 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/5078 |
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