Mucosal immune responses following intestinal nematode infection

Zaph, C., Cooper, Philip and Harris, N. L. (2014) 'Mucosal immune responses following intestinal nematode infection'. Parasite Immunology, Vol 36, Issue 9, pp. 439-452.

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Abstract

In most natural environments, the large majority of mammals harbour parasitic helminths that often live as adults within the intestine for prolonged periods (1–2 years) [1]. Although these organisms have been eradicated to a large extent within westernized human populations, those living within rural areas of developing countries continue to suffer from high infection rates. Indeed, recent estimates indicate that approximately 2·5 billion people worldwide, mainly children, currently suffer from infection with intestinal helminths (also known as geohelminths and soil-transmitted helminths) [1, 2]. Paradoxically, the eradication of helminths is thought to contribute to the increased incidence of autoimmune diseases and allergy observed in developed countries. In this review, we will summarize our current understanding of host–helminth interactions at the mucosal surface that result in parasite expulsion or permit the establishment of chronic infections with luminal dwelling adult worms. We will also provide insight into the adaptive immune mechanisms that provide immune protection against re-infection with helminth larvae, a process that is likely to be key to the future development of successful vaccination strategies. Lastly, the contribution of helminths to immune modulation and particularly to the treatment of allergy and inflammatory bowel disease will be discussed.

Item Type:	Article
Additional Information:	Special Issue: Mucosal Immunology
Subjects:	QW Microbiology and Immunology > Immunity by Type > QW 563 Local immunity QW Microbiology and Immunology > Immune Responses > QW 700 Infection. Mechanisms of infection and resistance. QX Parasitology > Helminths. Annelida > QX 203 Nematoda QX Parasitology > QX 45 Host-parasite relations
Faculty: Department:	Biological Sciences > Department of Tropical Disease Biology
Digital Object Identifer (DOI):	https://doi.org/10.1111/pim.12090
Depositing User:	Lynn Roberts-Maloney
Date Deposited:	12 May 2015 09:05
Last Modified:	06 Feb 2018 13:09
URI:	https://archive.lstmed.ac.uk/id/eprint/5131

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