Proinflammatory Responses and Higher IL-10 Production by T Cells Correlate with Protection against Malaria during Pregnancy and Delivery Outcomes

Requena, Pilar, Barrios, D., Robinson, L. J., Samol, P., Umbers, A. J., Wangnapi, R., Ome-Kaius, M., Rosanas-Urgell, A., Mayor, A., Lopez, M., de Lazzari, E., Arevalo-Herrera, M., Fernandez-Becerra, C., del Portillo, H., Chitnis, C. E., Siba, P. M., Rogerson, S., Mueller, I., Bardaji, A., Menendez, C. and Dobano, C. (2015) 'Proinflammatory Responses and Higher IL-10 Production by T Cells Correlate with Protection against Malaria during Pregnancy and Delivery Outcomes'. Journal of Immunology, Vol 194, Issue 7, pp. 3275-3285.

Full text not available from this repository.

Abstract

Pregnancy triggers immunological changes aimed to tolerate the fetus. However, it has not been properly addressed whether similar changes occur in tropical areas with high infection pressure and whether these changes render women more susceptible to infectious diseases. We compared the frequencies of T cell subsets, including regulatory T cells, in pregnant and nonpregnant women from Papua New Guinea, a high malaria transmission area, and from Spain, a malaria-free country. We also assessed the relationship among these cellular subsets, malaria infection, and delivery outcomes. CD4+FOXP3+CD127low T cells (Tregs) were decreased in pregnant women in both countries but were not associated with malaria infection or poor delivery outcomes. An expansion of IFN-γ–producing cells and intracytoplasmic IFN-γ levels was found in pregnant compared with nonpregnant women only in Papua New Guinea. Increased CD4+IL-10+IFN-γ+ frequencies and Treg–IFN-γ production were found in women with current Plasmodium falciparum infection. Higher CD4+IL-10−IFN-γ+ T cells frequencies and production of proinflammatory cytokines (including TNF and IL-2) at recruitment (first antenatal visit) had a protective association with birth weight and future (delivery) P. falciparum infection, respectively. Higher intracellular IL-10 levels in T cells had a protective association with future P. falciparum infection and hemoglobin levels at delivery. The protective associations were found also with nonmalaria-specific T cell responses. Treg frequencies positively correlated with plasma eotaxin concentrations, but this subset did not express eotaxin receptor CCR3. Thus, an activated immune system during pregnancy might contribute to protection against malaria during pregnancy and poor delivery outcomes.

Item Type:	Article
Subjects:	QU Biochemistry > Cells and Genetics > QU 300 General works QW Microbiology and Immunology > Reference Works. General Immunology > QW 520 Research (General) WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria WQ Obstetrics > Pregnancy > WQ 200 General works
Faculty: Department:	Biological Sciences > Department of Tropical Disease Biology
Digital Object Identifer (DOI):	https://doi.org/10.4049/jimmunol.1401038
Depositing User:	Lynn Roberts-Maloney
Date Deposited:	22 Sep 2015 13:05
Last Modified:	06 Feb 2018 13:10
URI:	https://archive.lstmed.ac.uk/id/eprint/5329

Statistics

View details

Actions (login required)

Edit Item